DIVERGENT MORTALITY FOR MALE AND FEMALE RECIPIENTS OF LOW-TITER AND HIGH-TITER MEASLES-VACCINES IN RURAL SENEGAL
DIVERGENT MORTALITY FOR MALE AND FEMALE RECIPIENTS OF LOW-TITER AND HIGH-TITER MEASLES-VACCINES IN RURAL SENEGAL
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DOI：
10.1093/oxfordjournals.aje.a116912
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发表时间：
1993-11-01
影响因子：
5
通讯作者：
WHITTLE, H
中科院分区：
文献类型：
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作者：
AABY, P;SAMB, B;WHITTLE, H
对塞内加尔农村地区1985-1991年期间出生的所有儿童进行了未免疫儿童和接种标准或高滴度麻疹疫苗的儿童的女性/男性死亡率调查。未接种疫苗儿童9个月至5岁的女性/男性死亡率为0.94（95%置信区间（CI）0.75-1.19），与施瓦茨标准麻疹疫苗接种者的0.64（95% CI 0.48-0.85）的比率存在显著差异（p = 0.040）。在研究区域使用高滴度麻疹疫苗的4年期间，高滴度Edmonston-Zagreb或施瓦茨疫苗接种者的女性/男性死亡率比为1.33（95% CI 1.00-1.78），而施瓦茨标准疫苗接种者为0.67（95% CI 0.42-1.07）（p = 0.013）。因此，施瓦茨标准和高滴度麻疹疫苗对整个儿童期的死亡率具有不同的性别特异性影响。需要对潜在机制进行进一步研究。
The female/male mortality ratio among unimmunized children and children vaccinated with standard or high-titer measles vaccines was examined for all children born in the period 1985-1991 in a rural area of Senegal. The female/male mortality ratio from 9 months to 5 years of age for unvaccinated children was 0.94 (95% confidence interval (CI) 0.75-1.19), significantly different from the ratio of 0.64 (95% Cl 0.48-0.85) for recipients of the Schwarz standard measles vaccine (p = 0.040). In the 4-year period, where high-titer measles vaccines were used in the study area, the female/male mortality ratio was 1.33 (95% Cl 1.00-1.78) for recipients of high-titer Edmonston-Zagreb or Schwarz vaccines compared with 0.67 (95% Cl 0.42-1.07) for recipients of the Schwarz standard vaccine (p = 0.013). Hence, the Schwarz standard and high-titer measles vaccines have divergent sex-specific effects on mortality throughout childhood. Further studies of the underlying mechanisms are needed.