Renoprotective effects of Caraway (Carum carvi L.) essential oil in streptozotocin induced diabetic rats
Renoprotective effects of Caraway (Carum carvi L.) essential oil in streptozotocin induced diabetic rats
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香菜精油对链脲佐菌素诱导的糖尿病大鼠的肾脏保护作用
DOI：
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发表时间：
2014
影响因子：
--
通讯作者：
Nermeen M. Shaffie
中科院分区：
文献类型：
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作者：
N. El;N. A. El;Gamila S. M. El;Mohamed S. Wahby;Nermeen M. Shaffie
文章历史：本研究的目的是评估Carum carvi精油的肾脏保护作用。将30只雄性白化病大鼠分为正常对照组（A组）、糖尿病阳性对照组（B组）和实验组（C组），实验组大鼠经口给予10 mg/kg体重的葛缕子油作为肾保护剂。B组和C组大鼠给予链脲佐菌素（60 mg/kg）诱导糖尿病模型。空腹血糖水平超过200 mg/dl的大鼠被认为是糖尿病。第22天采血测定谷胱甘肽过氧化物酶和葡萄糖。还取出肾脏进行检查。采用GC和GC/MS分析了葛缕子油。香菜挥发油的主要成分为香芹酮（70.1%），其次为γ -萜品烯（12.6%）和柠檬烯（5.5%），以及芳樟醇（0.7%）、百里酚（0.5%）、γ -杜松烯（0.5%）、α-金合欢烯（0.4%）、δ-杜松烯（0.4%）等。糖尿病组大鼠血糖升高，谷胱甘肽过氧化物酶降低。B组大鼠肾脏形态学检查显示肾小球和肾小管变性，大量细胞浸润，间质出血，肾组织结构变形。而C组大鼠肾脏组织病理改变轻微，明显改善。结论：葛缕子油对糖尿病肾病具有肾脏保护作用。这可能是由于葛缕子中含有香芹酮、γ -萜品烯和柠檬烯等具有较强的抗氧化活性。
Article history: Aim of the study was to assess the renoprotective effect of Carum carvi essential oil. Thirty male albino rats were divided into three groups: normal control (group A), diabetic positive control (group B), and experimental (group C) receiving Carum carvi oil as a renoprotective agent at 10 mg/kg of body weights orally. Group B and C rats received STZ (60 mg/kg) for induction of diabetes. Rats with fasting blood glucose levels over 200mg /dl were considered diabetic. Blood samples were collected on the 22 th day for the determination of glutathione peroxidase and glucose. Kidneys were also extracted for examination. Carum carvi oil was analysed using the GC and GC/MS analysis. The major components of caraway essential oil were Carvone (70.1%) followed by γ - Terpinene (12.6%) and Limonene (5.5%) in addition to some minor compounds including Linalool (0.7%), Thymol (0.5%), γ -Cadinene (0.5%), α- Farnesene (0.4%), δ- Cadinene (0.4%). The diabetic group rats showed an increase in the serum level of glucose, and decrease in glutathione peroxidase. 10 mg/kg body weight dose of Carum carvi oil significantly corrected these parameters.The morphological examination of group B rats kidneys showed glomerular and tubular degeneration with massive cellular infiltration, hemorrhage in interstitial tissue and deformed renal tissue architecture. Whereas the kidney rats in group C showed marked improvement with minor pathological changes. Conclusion: Carum carvi oil showed renoprotection against diabetic nephropathy. This could be contributed to Carum carvi constituents, especially carvone , γ -Terpinene and Limonene which have strong anti-oxidant activity.
DOI：
10.1016/s0021-9258(17)36966-1
发表时间：
1994-04
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Shi Du YanS;A. Schmidt;Mark Anderson;Jinghua Zhang;J. Brett;Y. Zou;D. Pinsky;David SternSn
通讯作者：
Shi Du YanS;A. Schmidt;Mark Anderson;Jinghua Zhang;J. Brett;Y. Zou;D. Pinsky;David SternSn