Treating atherosclerosis with regulatory T cells.
Treating atherosclerosis with regulatory T cells.
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DOI：
10.1161/atvbaha.114.303568
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发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Kuiper J
中科院分区：
文献类型：
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作者：
Foks AC;Lichtman AH;Kuiper J
调节性 T 细胞 (Treg) 通过抑制 T 细胞增殖和分泌抑制性细胞因子（如 IL-10 和 TGF-β），在调节 T 细胞介导的免疫反应中发挥重要作用。 Treg 数量和功能受损与多种疾病有关，促炎症/促动脉粥样硬化细胞与 Tregs 之间的不平衡会促进动脉粥样硬化疾病。通过诱导 Tregs 恢复这种平衡对于预防心血管疾病具有巨大的治疗潜力。除了抑制效应 T 细胞的分化和功能外，Treg 还被证明可以诱导抗炎巨噬细胞、抑制泡沫细胞形成并影响胆固醇代谢。此外，Tregs 抑制内皮细胞和先天淋巴细胞的免疫反应。在这篇综述中，我们重点关注 Treg 亚群的最新知识、它们在动脉粥样硬化中的活性和功能，并讨论使用 Treg 作为预防心血管疾病的治疗工具的有前途的策略。
Regulatory T cells (Tregs) play an important role in the regulation of T cell-mediated immune responses through suppression of T cell proliferation and secretion of inhibitory cytokines such as IL-10 and TGF-β. Impaired Treg numbers and function have been associated with numerous diseases and an imbalance between pro-inflammatory/pro-atherogenic cells and Tregs promotes atherosclerotic disease. Restoration of this balance by inducing Tregs has great therapeutic potential to prevent cardiovascular disease. In addition to suppressing differentiation and function of effector T cells, Tregs have been shown to induce anti-inflammatory macrophages, inhibit foam cell formation and to influence cholesterol metabolism. Furthermore, Tregs suppress immune responses of endothelial cells and innate lymphoid cells. In this review we focus on the recent knowledge on Treg subsets, their activity and function in atherosclerosis and discuss promising strategies to use Tregs as a therapeutic tool to prevent cardiovascular disease.