Relationship between the Foveal Avascular Zone and Foveal Pit Morphology
Relationship between the Foveal Avascular Zone and Foveal Pit Morphology
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DOI：
10.1167/iovs.11-8488
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发表时间：
2012-03-01
影响因子：
4.4
通讯作者：
Carroll, Joseph
中科院分区：
文献类型：
--
作者：
Dubis, Adam M.;Hansen, Benjamin R.;Carroll, Joseph
目的。目的探讨中央凹凹形态与中央凹无血管区（FAZ）大小的关系。共招募了42名受试者。使用光谱域光学相干断层扫描获得黄斑的体积图像。使用改进的眼底相机或自适应光学扫描光检眼镜获得FAZ图像。从视网膜厚度数据中自动提取中央凹凹坑指标（深度、直径、斜率、体积和面积），而FAZ由两个观察者手动分割以提取FAZ直径和面积的估计值。与先前的报道一致，作者观察到中央凹凹形态的显著变化。平均中央凹体积为0.081 mm(3)（范围0.022 ~ 0.190 mm(3)）。FAZ的面积在0.05 ~ 1.05 mm(2)之间，直径在0.20 ~ 1.08 mm之间，人与人之间的差异也很大。FAZ面积与中央凹面积、深度、体积呈显著相关；更深和更宽的中央凹与更大的faz相关。虽然这些结果与现有的中央凹发育模型的预测一致，但需要更多的工作来确认FAZ的大小与中央凹挖掘程度之间的发展联系。此外，需要更多的工作来了解这些与人类中央凹区域的其他解剖特征之间的关系，包括峰锥密度、无棒区直径和Henle纤维层。（Invest Ophthalmol Vis Sci. 2012;53:1628-1636） DOI:10.1167/iovs.11-8488
PURPOSE. To assess the relationship between foveal pit morphology and size of the foveal avascular zone (FAZ).METHODS. Forty-two subjects were recruited. Volumetric images of the macula were obtained using spectral domain optical coherence tomography. Images of the FAZ were obtained using either a modified fundus camera or an adaptive optics scanning light ophthalmoscope. Foveal pit metrics (depth, diameter, slope, volume, and area) were automatically extracted from retinal thickness data, whereas the FAZ was manually segmented by two observers to extract estimates of FAZ diameter and area.RESULTS. Consistent with previous reports, the authors observed significant variation in foveal pit morphology. The average foveal pit volume was 0.081 mm(3) (range, 0.022 to 0.190 mm(3)). The size of the FAZ was also highly variable between persons, with FAZ area ranging from 0.05 to 1.05 mm(2) and FAZ diameter ranging from 0.20 to 1.08 mm. FAZ area was significantly correlated with foveal pit area, depth, and volume; deeper and broader foveal pits were associated with larger FAZs.CONCLUSIONS. Although these results are consistent with predictions from existing models of foveal development, more work is needed to confirm the developmental link between the size of the FAZ and the degree of foveal pit excavation. In addition, more work is needed to understand the relationship between these and other anatomic features of the human foveal region, including peak cone density, rod-free zone diameter, and Henle fiber layer. (Invest Ophthalmol Vis Sci. 2012;53:1628-1636) DOI:10.1167/iovs.11-8488