Interleukin-11 and IL-17 and the pathogenesis of periodontal disease
Interleukin-11 and IL-17 and the pathogenesis of periodontal disease
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DOI：
10.1902/jop.2004.75.1.37
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发表时间：
2004-01-01
影响因子：
4.3
通讯作者：
Serio, FG
中科院分区：
文献类型：
--
作者：
Johnson, RB;Wood, N;Serio, FG
背景：白细胞介素 (IL) -11 和 IL-17 是调节炎症过程的细胞因子，尚未在正常或发炎牙龈组织中进行评估。我们的目的是比较健康和患病人类牙龈内的人 IL-11 和 IL-17 浓度，以确定它们在牙周病发生或进展中可能发挥的作用。 方法：对健康牙龈（邻近 3 mm 龈沟的非出血性牙龈）和患病牙龈（邻近 3 mm 牙周袋的出血性牙龈）进行活检。通过酶联免疫吸附测定评估溶解的牙龈活检中的 IL-11、IL-17、RANTES 和 IL-6 浓度。通过因子方差分析和事后 Tukey 真实显着性差异 (HSD) 检验对数据进行比较。回归分析和偏相关分析（根据样本重量进行调整）也用于确定变量之间的相关性。结果：白细胞介素 11 浓度在邻近 3 毫米病变袋的牙龈内最高（P
Background: Interleukin (IL) -11 and IL-17 are cytokines that modulate the inflammatory process and have not been assessed within normal or inflamed gingival tissues. Our purpose was to compare concentrations of human IL-11 and IL-17 within healthy and diseased human gingiva to determine their possible role in the initiation or progression of periodontal diseases.Methods: Biopsies from healthy (non-hemorrhagic gingiva adjacent to a 3 mm gingival sulcus) and diseased gingiva (hemorrhagic gingiva adjacent to a 3 mm periodontal pocket) were studied. IL-11, IL-17, RANTES, and IL-6 concentrations were assessed within solubilized gingival biopsies by enzyme-linked immunosorbent assay. Data were compared by factorial analysis of variance and a post-hoc Tukey honestly significant difference (HSD) test. Regression analysis and partial correlation analysis (adjusted for sample weight) were also used to determine correlations between the variables.Results: Interleukin-11 concentrations were highest within gingiva adjacent to 3 mm diseased pockets (P