Regional homogeneity changes in patients with primary insomnia
Regional homogeneity changes in patients with primary insomnia
复制标题
原发性失眠患者的区域同质性变化
DOI：
10.1007/s00330-015-3960-4
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发表时间：
2016-05-01
影响因子：
5.9
通讯作者：
Tian, Junzhang
中科院分区：
文献类型：
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作者：
Wang, Tianyue;Li, Shumei;Tian, Junzhang
目的探讨原发性失眠(PI)患者局部自发活动的变化。材料与方法基于59例PI患者和47例健康对照的静息状态fMRI数据，对个体归一化区域同质性(ReHO)图进行两样本t检验。结果PI患者左侧脑岛、右侧扣带前回、双侧中央前回和左侧楔状回REHO升高，右侧扣带回中叶和左侧梭状回REHO降低(P<； 0.0 5，AlphaSim校正)。左侧脑岛REHO升高与焦虑自评量表评分呈显著正相关，右侧扣带回中回REHO评分与抑郁自评量表评分呈显著正相关，右侧中央前回REHO评分与抑郁自评量表评分呈负相关(p<； 0.0 5)。这些区域的活动变化可能有助于了解失眠的内在功能结构及其临床特征。关键点·PI患者可检测到区域自发活动的变化。·PI患者某些区域的ReHO降低或增加。·平均ReHO与抑郁评分显著相关。
PurposeThe study aimed to explore the regional spontaneous activity changes in primary insomnia (PI) patients.Materials and methodsBased on the resting-state fMRI datasets acquired from 59 PI patients and 47 healthy controls, a two-sample t-test was performed on individual normalized regional homogeneity (ReHo) maps. Relationships between abnormal ReHo values and the Pittsburgh Sleep Quality Index (PSQI), the self-rating anxiety scale (SAS) and the self-rating depression scale (SDS) were investigated with Pearson correlation analysis.ResultsIn PI patients, we found increased ReHo in the left insula, right anterior cingulate gyrus, bilateral precentral gyrus and left cuneus, as well as decreased ReHo in the right middle cingulate cortex and left fusiform (p< 0.05, AlphaSim-corrected). We also found a significant positive correlation between increased ReHo in the left insula and SAS scores, decreased ReHo in the right middle cingulated cortex and SDS, SAS scores as well as a negative correlation between increased ReHo in the right precentral gyrus and SDS scores (p< 0.05).ConclusionsOur study found abnormal spontaneous activities in multiple brain regions, especially in emotion-related areas in PI patients. Alterative activities in these regions might contribute to an understanding the intrinsic functional architecture of insomnia and its clinical features.Key Points•Regional spontaneous activity changes were detected in PI patients.•Decreased or increased ReHo of some regions was identified in PI patients.•Significant correlations between mean ReHo and SDS scores were found.