HISTAMINE AND 5-HYDROXYTRYPTAMINE IN INTESTINAL TRACT OF GERM-FREE ANIMALS, ANIMALS HARBOURING 1 MICROBIAL SPECIES AND CONVENTIONAL ANIMALS
HISTAMINE AND 5-HYDROXYTRYPTAMINE IN INTESTINAL TRACT OF GERM-FREE ANIMALS, ANIMALS HARBOURING 1 MICROBIAL SPECIES AND CONVENTIONAL ANIMALS
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DOI：
10.1111/j.1476-5381.1962.tb01443.x
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发表时间：
1962-01-01
期刊：
影响因子：
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通讯作者：
WOSTMANN, BS
中科院分区：
文献类型：
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作者：
BEAVER, MH;WOSTMANN, BS
测定无菌和常规大鼠、小鼠肠道组胺和5-羟色胺含量。在单产气荚膜梭菌相关的大鼠中收集了可比的组胺数据，而5-羟色胺的测定扩展到包括鸡。在拥有肠道菌群的大鼠和小鼠中，组胺的细菌形成主要发生在盲肠。与无菌动物相比，常规动物小肠壁上的组胺含量往往更高，尽管在大鼠身上的数据并不一致。无菌大鼠与产组胺的产气荚膜荚膜梭菌的单结合（含一种微生物）导致盲肠内容物中的组胺浓度较高，但未能增加小肠壁中的组胺水平。肠道菌群存在时，肠道壁上的5-羟色胺水平通常低于无菌动物。通过给小鼠喂食青霉素来改变菌群，部分地消除了它的抑制作用。
Histamine and 5-hydroxytryptamine were determined in the intestinal tract of germ-free and conventional rats and mice. Comparable histamine data were collected in Clostridium perfringens mono-associated rats, while 5-hydroxytryptamine determinations were extended to include the chicken. In rats and mice harboring an intestinal microflora, bacterial formation of histamine occurs mainly in the cecum. Compared to values found in germ-free animals, histamine levels in the wall of the small intestine of the conventional animal tend to be higher, though in the rat the data are not consistent. Mono-association (harboring of one microbial species) of germ-free rats with a histamine-producing strain of C. perfringens resulted in high histamine concentrations in the cecal contents, but failed to increase the histamine levels in the wall of the small intestine. 5-Hydroxytryptamine levels in the intestinal wall in the presence of an intestinal flora were generally lower than those in germ-free animals. Modification of the flora by dietary administration of penicillin to mice partly abolished its depressing effect.