Synthetic Approach to Telomerase Inhibitor Dictyodendrin B: Synthesis of the Pyrrolo[2,3-c]carbazole Core
Synthetic Approach to Telomerase Inhibitor Dictyodendrin B: Synthesis of the Pyrrolo[2,3-c]carbazole Core
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DOI：
10.1271/bbb.90111
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发表时间：
2009-08-01
影响因子：
1.6
通讯作者：
Ishibashi, Fumito
中科院分区：
文献类型：
--
作者：
Hirao, Shotaro;Sugiyama, Yumiko;Ishibashi, Fumito
以钯催化的3-aryl-1-(2-arylethyl)-4-hydroxy-2，5-bismethoxycarbonylpyrrole三氟酸酯与7-烷氧基吲哚-3-硼酸酯的交叉偶联反应为关键步骤，合成了端粒酶抑制剂Dittyodendrin B的核心结构。
The core structure of the telomerase inhibitor, dictyodendrin B, was synthesized by using the palladium-catalyzed cross-coupling reaction of 3-aryl-1-(2-arylethyl)-4-hydroxy-2,5-bismethoxycarbonylpyrrole triflate with 7-alkoxyindole-3-boronate as the key step.