Rhythmic Continuous-Time Coding in the Songbird Analog of Vocal Motor Cortex
Rhythmic Continuous-Time Coding in the Songbird Analog of Vocal Motor Cortex
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DOI：
10.1016/j.neuron.2016.04.021
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发表时间：
2016-05-18
期刊：
影响因子：
16.2
通讯作者：
Fee, Michale S.
中科院分区：
文献类型：
--
作者：
Lynch, Galen F.;Okubo, Tatsuo S.;Fee, Michale S.
鸣禽学习并产生复杂的声音手势序列。成年鸟鸣需要前运动核团HVC，在鸣声中，投射神经元(PN)在刻板的时间稀疏地爆发。已有的假说认为，PN爆发作为一个群体形成了一个连续的序列，而HVC功能的另一种模型认为，HVC PN和神经元间活动都紧紧围绕着运动手势组织。使用记录在鸣禽中的三叉神经节和中间神经元的大型数据集，我们测试了这些模型的几个预测。我们发现，成鸟的Pn爆发在整个鸣唱过程中持续且几乎均匀地分布。然而，我们也发现，Pn和神经元间放电频率显示出显著的10-Hz节律性，与歌曲音节相关，在音节开始之前达到峰值，在偏移之前被抑制-在发声学习的早期阶段，这种模式主导着Pn和HVC中的中间神经元活动。
Songbirds learn and produce complex sequences of vocal gestures. Adult birdsong requires premotor nucleus HVC, in which projection neurons (PNs) burst sparsely at stereotyped times in the song. It has been hypothesized that PN bursts, as a population, form a continuous sequence, while a different model of HVC function proposes that both HVC PN and interneuron activity is tightly organized around motor gestures. Using a large dataset of PNs and interneurons recorded in singing birds, we test several predictions of these models. We find that PN bursts in adult birds are continuously and nearly uniformly distributed throughout song. However, we also find that PN and interneuron firing rates exhibit significant 10-Hz rhythmicity locked to song syllables, peaking prior to syllable onsets and suppressed prior to offsets-a pattern that predominates PN and interneuron activity in HVC during early stages of vocal learning.