Generation of interneuron diversity in the mouse cerebral cortex
Generation of interneuron diversity in the mouse cerebral cortex
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DOI：
10.1111/j.1460-9568.2010.07267.x
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发表时间：
2010-06-01
影响因子：
3.4
通讯作者：
Marin, Oscar
中科院分区：
文献类型：
--
作者：
Gelman, Diego M.;Marin, Oscar
含γ-氨基丁酸（GABA能）的中间神经元在大脑皮层的功能中起重要作用。通过主要的抑制机制，中间神经元控制过度兴奋，并同步和塑造各种大脑功能背后的皮层活动的时空动力学。它们对皮质功能的影响是非常多样的，反映了哺乳动物皮质中存在的大量不同的神经元间群体。过去几年的研究已经迅速改变了我们对不同类别中间神经元产生机制的理解。在这篇综述中，我们总结了这一过程的最新进展，进展持有的承诺，提供一个合理的框架，他们的分类，以及手段，以了解他们在皮层处理的作用。
Gamma-aminobutyric acid-containing (GABAergic) interneurons play an important role in the function of the cerebral cortex. Through mostly inhibitory mechanisms, interneurons control hyperexcitability, and synchronize and shape the spatiotemporal dynamics of cortical activity underlying various brain functions. Their influence on cortical function is remarkably diverse, a reflection of the large variety of interneuronal populations that exist in the mammalian cortex. Research over the past few years has rapidly transformed our understanding of their mechanisms underlying the generation of different classes of interneurons. In this review, we summarize recent progress on this process, progress which holds the promise of providing a rational framework for their classification, as well as means to understand their role in cortical processing.