Determination of iron absorption from whole diet. A new two-pool model using two radioiron isotopes given as haem and non-haem iron.
Determination of iron absorption from whole diet. A new two-pool model using two radioiron isotopes given as haem and non-haem iron.
复制标题
测定整个饮食中铁的吸收。
DOI：
10.1111/j.1600-0609.1972.tb00930.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
E. Björn
中科院分区：
文献类型：
--
作者：
L. Hallberg;E. Björn
初步数据强烈表明，有一个完整的同位素交换之间添加的无机铁示踪剂和非血红素铁化合物在一些食品充分混合时，在准备过程中的食物。这种示踪剂的吸收预期给出从饮食中非血红素铁的总吸收的真实测量。同样，有证据表明，放射性铁标记的血红蛋白可作为示踪剂的研究血红素铁的吸收从饮食。提出了食物铁吸收的两库模型--一个血红素铁库和一个非血红素铁库。这些池可以通过使用两种不同的放射性铁同位素独立地标记无机放射性铁示踪剂和放射性铁标记的血红蛋白。来自这些池（来自整个饮食）的铁的总吸收可以通过使用全身计数和确定血液样品中的/sup 55/Fe//sup 59/Fe比率的/sup 59/Fe的全身保留的组合测量来测量。本文还报告了这种方法在正常人和缺铁人中的应用。（auth）
Preliminary data strongly indicate that there is a complete isotopic exchange between an added inorganic iron tracer and non-haem iron compounds in a number of foodstuffs when thoroughly mixed with the food during preparation. The absorption of such a tracer is expected to give a true measure of the total absorption of non-haem iron from the diet. Similarly there is evidence indicating that radioiron-labeled hemogiobin may be used as a tracer for studies on haem iron absorption from the diet. A two-pool model is suggested for food iron absorption---one haem iron and one non-haem iron pool. These pools can be independently labeled with an inorganic radioiron tracer and with radioiron- labeled hemoglobin by using two different radioiron isotopes. The total absorption of iron from these pools (from the whole diet) can be measured from the combined measurement of total body retention of /sup 59/Fe using whole body counting and determination of the ratio /sup 55/Fe//sup 59/Fe in a blood sample. A report of preliminary studies on the application of this method in normal and iron deficient men is also given. (auth)