Morphological evidence for existence of IL-6 receptor alpha in the glomus cells of rat carotid body
Morphological evidence for existence of IL-6 receptor alpha in the glomus cells of rat carotid body
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DOI：
10.1002/ar.a.20310
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发表时间：
2006-03-01
期刊：
影响因子：
--
通讯作者：
Wang, BR
中科院分区：
文献类型：
--
作者：
Wang, X;Zhang, XJ;Wang, BR
颈动脉小体(CB)感知动脉血PO的变化，调节呼吸运动。人们普遍认为CB中的多巴胺能I型细胞是化学感受器。然而，颈动脉小体是否具有感知促炎细胞因子刺激的能力尚不清楚。白介素6(IL-6)作为一种多功能细胞因子，在宿主防御机制中起着关键作用。本研究采用免疫组织化学、Western blotts和原位杂交等方法，观察了IL-6Rα在颈动脉小体中的表达。结果证实在大鼠颈动脉体球细胞中存在IL-6Rα蛋白和mRNAs。这些结果提示，促炎症细胞因子可能通过其受体影响颈动脉小体的功能。(C)2006年Wiley-Liss，Inc.
The carotid body (CB) senses changes in arterial blood PO, and modulates respiratory movement. It is generally accepted that the dopaminergic type I cells in the CB are chemoreceptors. However, it has not been clarified whether the carotid body has the ability to perceive the stimulation of proinflammatory cytokines. Interleukin 6 (IL-6) as a multifunctional cytokine plays a pivotal role in host defense mechanism. In the present study, we observed the expression of IL-6R alpha mRNA and protein in the carotid body using immunohistochemistry, Western blots, and in situ hybridization. The results confirmed the presence of IL-6R alpha proteins and mRNAs in the glomus cells of rat carotid body. These results suggest that the function of the carotid body may be influenced by the proinflammatrory cytokines through their receptors. (c) 2006 Wiley-Liss, Inc.