A Population-Based Study on the Association between Benign Prostatic Enlargement and Rheumatoid Arthritis
A Population-Based Study on the Association between Benign Prostatic Enlargement and Rheumatoid Arthritis
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DOI：
10.1371/journal.pone.0133013
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发表时间：
2015-07-14
期刊：
影响因子：
3.7
通讯作者：
Huang, Chao-Yuan
中科院分区：
文献类型：
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作者：
Tzeng, Ya-Mei;Kao, Li-Ting;Huang, Chao-Yuan
良性前列腺增生是老年男性慢性炎症之一。类风湿性关节炎（RA）是一种主要的自身免疫性疾病，也是一种慢性炎症性疾病。尽管RA和良性前列腺增大（BPE）可能具有相同的潜在病因，但几乎没有研究试图探讨RA和BPE之间的关系。本研究的目的是利用基于人群的数据集探讨RA和BPE之间的关系。本病例对照研究采用2005年台湾健康保险纵向数据库资料。该研究包括18,716例BPE患者和18,716例年龄匹配的非BPE患者。进行条件logistic回归分析以计算BPE患者与对照患者之间先前诊断为RA的比值比（OR）。在37,432例抽样患者中，总共有485例（1.3%）曾接受过RA诊断。既往RA患病率在病例和对照组之间存在显著差异(1.6% vs. 1.0%, p
Benign prostatic hyperplasia is one of the chronic inflammatory conditions in ageing male populations. Rheumatoid arthritis (RA) is a major autoimmune disease and is also regarded as a chronic inflammatory disorder. Although RA and benign prostatic enlargement (BPE) may share the same underlying etiologies, almost no study has ever attempted to explore the relationship between RA and BPE. The aim of this study was to explore the relationship between RA and BPE using a population-based dataset. This case-control study used data retrieved from the Taiwan Longitudinal Health Insurance Database 2005. This study comprised 18,716 patients with BPE and 18,716 age-matched patients without BPE. Conditional logistic regression analyses were performed to calculate the odds ratio (OR) for having been previously diagnosed with RA between patients with BPE and comparison patients. In total, 485 of the 37,432 sampled patients (1.3%) had received a prior RA diagnosis. There was a significant difference in the prevalence of prior RA between cases and controls (1.6% vs. 1.0%, p