DNA fragmentation in targets of CTL: an example of programmed cell death in the immune system.
DNA fragmentation in targets of CTL: an example of programmed cell death in the immune system.
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CTL 靶标中的 DNA 片段化：免疫系统中程序性细胞死亡的一个例子。
DOI：
10.1007/978-1-4684-8326-0_32
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发表时间：
1985
影响因子：
--
通讯作者：
Olson,LK
中科院分区：
文献类型：
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作者：
Cohen,JJ;Duke,RC;Chervenak,R;Sellins,KS;Olson,LK
我们对T细胞介导的细胞毒性的研究源于对程序性细胞死亡机制的兴趣。后生动物体内细胞的死亡可分为功能性、形态学和生物化学三大类。在功能层面上，细胞死亡通常是系统可接受或期望的;它是设计的一部分。这种程序性细胞死亡的例子包括形态发生性死亡，其发生在早期发育期间并有助于器官和肢体的形成;具有正常细胞更新的系统中的死亡，例如上皮细胞或多形核嗜中性粒细胞;以及依赖细胞的组织的退化。与这种功能上可接受的细胞死亡相反的是意外死亡，例如可能伴随物理、化学或缺氧损伤以及某些细菌和病毒感染。
Our studies of T cell-mediated cytotoxicity grew out of an interest in the mechanism of programmed cell death. The death of cells in the metazoan body can be categorized functionally, morphologically and biochemically. On the functional level, cell death is often acceptable or desirable for the system; it is part of the design. Examples of this programmed cell death include morphogenetic death, which occurs during early development and helps shape organs and limbs; death in systems with a normal cell turnover, for example epithelia or polymorphonuclear neutrophils; and the involution of hormone-dependent tissues. Opposed to this functionally acceptable cell death is accidental death, such as might follow physical, chemical or anoxic injury, and certain bacterial and viral infections.