Role of M1-polarized tumor-associated macrophages in the prognosis of advanced ovarian cancer patients
Role of M1-polarized tumor-associated macrophages in the prognosis of advanced ovarian cancer patients
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DOI：
10.1038/s41598-020-63276-1
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发表时间：
2020-04-08
影响因子：
4.6
通讯作者：
Madeddu, Clelia
中科院分区：
文献类型：
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作者：
Maccio, Antonio;Gramignano, Giulia;Madeddu, Clelia
识别预后和预测标志物对于选择最合适的卵巢癌患者管理方法至关重要。我们旨在评估肿瘤相关巨噬细胞（TAM）极化在晚期卵巢癌患者中的预后作用。我们进行了一项前瞻性观察性研究，纳入了2013年6月至2018年12月期间140例连续晚期高级别浆液性卵巢癌患者以及其他组织型卵巢癌患者和其他部位卵巢转移患者。患者在腹腔镜手术时入组，然后接受任何腹腔镜治疗。我们发现，与其他患者相比，高级别浆液性乳头状卵巢癌患者的M1 TAM患病率较高，M1/M2比值较高，总生存期（OS）和无进展生存期（PFS）较长。回归分析证实，在整个人群和根据肿瘤类型和初次手术分层的患者中，M1/M2比值与OS、PFS和无铂间期（PFI）改善之间存在显著正相关。根据中位M1/M2比值将患者分为2组后进行Kaplan-Meier分析，结果显示M1/M2比值高的患者的OS、PFS和PFI高于M1/M2比值低的患者。总之，TAM极化在肿瘤微环境中的预后和预测作用可能具有很大的临床意义，并可能允许早期识别可能对治疗有反应的患者。需要在更大的前瞻性样本中进行进一步研究。
The identification of prognostic and predictive markers is crucial for choosing the most appropriate management method for ovarian cancer patients. We aimed to assess the prognostic role of tumor-associated macrophage (TAM) polarization in advanced ovarian cancer patients. We carried out a prospective observational study that included 140 consecutive patients with advanced-stage high-grade serous ovarian cancer as well as patients with other histotypes of ovarian cancer and patients with ovarian metastasis from other sites between June 2013 and December 2018. Patients were enrolled at the time of laparoscopic surgery before receiving any antineoplastic treatment. We found that patients with high-grade serous papillary ovarian cancers had a prevalence of M1 TAMs, a higher M1/M2 ratio, and a longer overall survival (OS) and progression-free survival (PFS) than other patients. Regression analysis confirmed that there was a significant positive association between the M1/M2 ratio and an improved OS, PFS and platinum-free interval (PFI), both in the entire population and in patients stratified according to tumor type and initial surgery. Kaplan-Meier analysis was performed after the patients were divided into 2 groups according to the median M1/M2 ratio and revealed that patients with a high M1/M2 ratio had a higher OS, PFS and PFI than those with a low M1/M2 ratio. In conclusion, the prognostic and predictive role of TAM polarization in the tumor microenvironment could be of great clinical relevance and may allow the early identification of patients who are likely to respond to therapy. Further studies in a larger prospective sample are warranted.