p53 as guardian of the mitochondrial genome.
p53 as guardian of the mitochondrial genome.
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DOI：
10.1002/1873-3468.12061
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发表时间：
2016-04
期刊：
影响因子：
3.5
通讯作者：
Hwang PM
中科院分区：
文献类型：
--
作者：
Park JH;Zhuang J;Li J;Hwang PM
参与细胞核DNA的修复是p53抑制肿瘤发生的一种机制，但越来越多的证据表明，p53也有助于维持线粒体基因组通过其易位到线粒体和与线粒体DNA修复蛋白的相互作用。由于线粒体DNA对氧化损伤和复制错误的敏感性，保护线粒体DNA基因组稳定性以保持健康和健身至关重要。在这里，我们重点审查的证据参与p53在维持线粒体DNA的完整性，通过其活动在细胞核和线粒体。
Participating in the repair of nuclear DNA is one mechanism by which p53 suppresses tumorigenesis, but there is growing evidence that p53 also helps maintain the mitochondrial genome through its translocation into mitochondria and interactions with mtDNA repair proteins. Because of the susceptibility of mtDNA to oxidative damage and replication errors, it is vital to protect mtDNA genomic stability to preserve health and fitness. Here, we focus on reviewing the evidence for the involvement of p53 in maintaining the integrity of mtDNA through its activities in both the nucleus and the mitochondria.