Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin.
Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin.
复制标题
使用含有庆大霉素的溶解微阵列贴片控制小鼠肺炎克雷伯菌感染。
DOI：
10.1128/aac.02612-18
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发表时间：
2019
影响因子：
4.9
通讯作者：
Rodgers AM
中科院分区：
文献类型：
--
作者：
Rodgers AM
利用肺炎克雷伯菌细菌感染的小鼠模型，我们证明了应用于小鼠耳朵的庆大霉素溶解微阵列贴片可以控制肺炎克雷伯菌的感染。与未治疗的小鼠相比，接受微阵列贴片治疗的小鼠鼻腔相关淋巴组织和肺部的细菌负荷减少。这项概念验证研究首次发表了通过溶解微阵列贴片活体传递抗生素庆大霉素的数据，从而控制了细菌感染。
Using a murine model of Klebsiella pneumoniae bacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control K. pneumoniae infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreated counterparts. This proof of concept study represents the first published data on thein vivodelivery of the antibiotic gentamicin via dissolving microarray patches, resulting in the control of bacterial infection.