Human seizures couple across spatial scales through travelling wave dynamics.
Human seizures couple across spatial scales through travelling wave dynamics.
复制标题
DOI：
10.1038/ncomms14896
复制
发表时间：
2017-04-04
影响因子：
16.6
通讯作者：
Kramer MA
中科院分区：
文献类型：
--
作者：
Martinet LE;Fiddyment G;Madsen JR;Eskandar EN;Truccolo W;Eden UT;Cash SS;Kramer MA
癫痫是一种经常性的、无缘无故的疾病，是一种毁灭性的疾病，影响着全世界6500万人。理解和治疗这种疾病仍然是一个挑战，因为癫痫发作通过跨越空间和时间尺度的机制和特征表现出来。在这里，我们通过分析和建模同时记录在微观和宏观空间尺度上的人脑电压活动来解决这一挑战。我们发现，在癫痫发作期间，跨越几厘米的皮层的大规模神经群体与跨越皮层列的小神经群协调，并提供证据表明，快速传播的活动波是这种增加的尺度间耦合的基础。我们开发了一个相应的计算模型，提出具体的机制，即增加细胞外钾浓度扩散在空间的影响，支持所观察到的时空动态。了解多尺度，时空动态的人类肿瘤，并将这些动态连接到特定的生物机制，承诺新的见解，以治疗这种毁灭性的疾病。作者记录了人类癫痫发作期间的局部和长程神经活动，以研究潜在的多尺度动力学。他们发现，在癫痫发作期间，通过传播波，通过结合神经活动和钾浓度动态的模型拟合，跨空间尺度的活动耦合增加。
Epilepsy—the propensity toward recurrent, unprovoked seizures—is a devastating disease affecting 65 million people worldwide. Understanding and treating this disease remains a challenge, as seizures manifest through mechanisms and features that span spatial and temporal scales. Here we address this challenge through the analysis and modelling of human brain voltage activity recorded simultaneously across microscopic and macroscopic spatial scales. We show that during seizure large-scale neural populations spanning centimetres of cortex coordinate with small neural groups spanning cortical columns, and provide evidence that rapidly propagating waves of activity underlie this increased inter-scale coupling. We develop a corresponding computational model to propose specific mechanisms—namely, the effects of an increased extracellular potassium concentration diffusing in space—that support the observed spatiotemporal dynamics. Understanding the multi-scale, spatiotemporal dynamics of human seizures—and connecting these dynamics to specific biological mechanisms—promises new insights to treat this devastating disease. The authors record both local and long-range neural activity during human epileptic seizures to study the underlying multi-scale dynamics. They find that coupling of activity across spatial scales increases during seizures through propagating waves that are fit by a model that combines neural activity and potassium concentration dynamics.