Steroid-induced pancreatitis.
Steroid-induced pancreatitis.
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类固醇诱发的胰腺炎。
DOI：
10.1001/jama.1965.03090180088027
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发表时间：
1965
期刊：
影响因子：
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通讯作者：
R. Bulger
中科院分区：
文献类型：
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作者：
R. Schrier;R. Bulger
肾上腺皮质激素治疗的并发症已被广泛报道，但与类固醇治疗相关的胰腺异常很少被包括在内。Carone和Liebow的一项尸检研究显示，54例接受促肾上腺皮质激素或肾上腺类固醇治疗的患者中，有16例有急性胰腺炎或胰周脂肪坏死的组织学证据。在54名年龄相仿、主要疾病相似的对照组中，只有2名患者出现了这些病理改变。这些患者均未被诊断为胰腺炎。1961年，Nelp 3回顾了文献并报告了他自己的6例临床表现为急性胰腺炎的病例，这些病例与肾上腺类固醇的使用有关。据我们所知，尚未报告其他病例。在先前报道的14例类固醇引起的症状性胰腺炎病例中，有12例直到探查性手术或尸检才做出诊断。3 - 8
THE COMPLICATIONS of therapy with adrenocortical hormones have been reviewed extensively, but the pancreatic abnormalities which occur in association with administration of steroids rarely have been included. 1 A postmortem study by Carone and Liebow 2 revealed histologic evidence of acute pancreatitis, or peripancreatic fat necrosis, in 16 of 54 patients treated with corticotropin or adrenal steroids. In a control group of 54 patients of comparable age and with similar major diseases, only two had these pathologic changes. The clinical diagnosis of pancreatitis was not made in any of these patients. In 1961 Nelp 3 reviewed the literature and reported six of his own cases of clinically manifest acute pancreatitis associated with the administration of adrenal steroids. To our knowledge, no additional cases have been reported. In 12 of 14 previously reported instances of symptomatic pancreatitis induced by steroids, the diagnosis was not made until exploratory surgery or autopsy. 3-8