Visual attention task performance in Wistar and Lister hooded rats: Response inhibition deficits after medial prefrontal cortex lesions
Visual attention task performance in Wistar and Lister hooded rats: Response inhibition deficits after medial prefrontal cortex lesions
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DOI：
10.1016/s0306-4522(99)00312-7
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发表时间：
1999-01-01
期刊：
影响因子：
3.3
通讯作者：
Uylings, HBM
中科院分区：
文献类型：
--
作者：
Broersen, LM;Uylings, HBM
传统上，前额叶皮层与多种认知过程有关，包括记忆、注意力和决策。前额皮质损伤对注意力影响的检测已被证明取决于用于评估注意力过程的程序。因此，我们研究了前额皮质损伤在两种不同视觉注意任务中的影响，即涉及持续和分散注意过程的三选择串行反应时间任务和涉及持续注意和反应抑制过程的视觉计时任务。在行为分析中经常使用的两种大鼠品系中，即白化 Wistar 大鼠和色素性 Lister 兜帽大鼠，内侧前额叶皮层的损伤导致这两项任务的表现下降，尽管这种影响在视觉计时任务中持续的时间要长得多。事实证明，后一项任务对于检测内侧前额叶皮层损伤的后果特别敏感，包括注意力控制和反应抑制的丧失。在这两项注意力任务中，Wistar 大鼠的准确度均低于 Listers，但做出的预期反应更多。品系差异不能完全归因于白化病患者可能存在的视觉缺陷，当评估开放领域的运动活动和囤积范式中的食物驱动行为时，这一点也很明显。由于适应速度较慢，Lister 大鼠更加活跃，几乎没有表现出食物囤积行为。在 Wistar 大鼠中，囤积行为被内侧前额叶皮层损伤破坏，显示了损伤的有效性。结果表明，尽管不同的大鼠品系为测试损伤或药物引起的行为变化提供了不同的行为基线水平，但内侧前额叶皮层的损伤不仅扰乱了持续的注意力过程，而且还会引起 Wistar 和 Lister 大鼠反应抑制的强烈损害。 (C) 1999 国际广播组织。由爱思唯尔科学有限公司出版
The prefrontal cortex has traditionally been implicated in a variety of cognitive processes, including memory, attention and decision making. The detection of effects of prefrontal cortex lesions on attention has been shown to depend on the procedure used to assess the attentional process. We therefore investigated the effects of lesions of the prefrontal cortex in two different visual attention tasks, i.e. a three-choice serial reaction time task involving sustained and divided attention processes and a visual timing task involving sustained attention and response inhibition processes. In two rat strains that are frequently used in behavioural analysis, i.e. albino Wistar rats and pigmented Lister Hooded rats, lesions of the medial prefrontal cortex caused a deterioration of performance in both tasks, although the effect lasted much longer in the visual timing task. This latter task proved to be especially sensitive to detect the consequences of medial prefrontal cortex lesions, consisting of a loss of both attention control and response inhibition. In both attention tasks, Wistar rats performed less accurate and made more anticipatory responses than Listers. Strain differences could not entirely be attributed to possible visual deficits in albinos, which was also evident when locomotor activity in an open field and food-motivated behaviour in a hoarding paradigm were assessed. Due to slower habituation rates, Lister rats were more active and displayed little food hoarding behaviour. In Wistar rats, hoarding was disrupted by medial prefrontal cortex lesions, showing the effectiveness of the lesion.The results indicate that, although different rat strains provide different baseline levels of behaviour for testing lesion- or drug-induced behavioural changes, lesions of the medial prefrontal cortex do not only disrupt sustained attention processes, but also induce a strong impairment in response inhibition in both Wistar and Lister rats. (C) 1999 IBRO. Published by Elsevier Science Ltd.