No Evidence of Increased Mutation Rates at Microsatellite Loci in Offspring of A-Bomb Survivors
No Evidence of Increased Mutation Rates at Microsatellite Loci in Offspring of A-Bomb Survivors
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DOI：
10.1667/rr1991.1
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发表时间：
2010-02-01
影响因子：
3.4
通讯作者：
Nakamura, N.
中科院分区：
文献类型：
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作者：
Kodaira, M.;Ryo, H.;Nakamura, N.
为了评估原子弹辐射的遗传效应，我们检测了暴露家庭（父亲-母亲-后代，主要是单亲暴露）中40个微卫星位点的突变，该家庭包括66个后代，父亲的平均剂量为1.87 Gy，母亲的平均剂量为1.27 Gy。对照家庭由63个后代组成，他们的父母要么受到低剂量辐射（< 0.01 Gy），要么在原子弹爆炸时不在广岛或长崎。我们在暴露的等位基因中发现了7个突变（7/ 2789；突变率0.25 × 10(-2)/位点/代），在未暴露的等位基因中发现了26个突变（26/ 7465;0.35 × 10(-2)/位点/代），这并不表明父母暴露于辐射的影响。虽然我们无法确定4个突变的亲本来源，但结论可能成立，因为即使我们假设这4个突变发生在暴露等位基因中，暴露组的平均突变率估计为0.39 X 10(-2)[(7 + 4)/ 2789)]，略高于对照组的0.35 X 10(-2)，但差异无统计学意义。(C) 2010年由辐射研究学会出版
To evaluate the genetic effects of A-bomb radiation, we examined mutations at 40 microsatellite loci in exposed families (father-mother-offspring, mostly uni-parental exposures), which consisted of 66 offspring having a mean paternal dose of 1.87 Gy and a mean maternal dose of 1.27 Gy. The control families consisted of 63 offspring whose parents either were exposed to low doses of radiation (< 0.01 Gy) or were not in the cities of Hiroshima or Nagasaki at the time of the bombs. We found seven mutations in the exposed alleles (7/2,789; mutation rate 0.25 X 10(-2)/locus/generation) and 26 in the unexposed alleles (26/7,465; 0.35 X 10(-2)/locus/generation), which does not indicate an effect from parental exposure to radiation. Although we could not assign the parental origins of four mutations, the conclusion may hold since even if we assume that these four mutations had occurred in the exposed alleles, the estimated mean mutation rate would be 0.39 X 10(-2) in the exposed group [(7 + 4)/2,789)], which is slightly higher than 0.35 X 10(-2) in the control group, but the difference is not statistically significant. (C) 2010 by Radiation Research Society