Predictive factors of radiation-induced skin toxicity in breast cancer patients.
Predictive factors of radiation-induced skin toxicity in breast cancer patients.
复制标题
DOI：
10.1186/1471-2407-10-508
复制
发表时间：
2010-09-23
期刊：
影响因子：
3.8
通讯作者：
Cheng YH
中科院分区：
文献类型：
--
作者：
Chen MF;Chen WC;Lai CH;Hung CH;Liu KC;Cheng YH
通过对乳腺癌患者接受辅助三维适形放疗的剂量学和局部治疗的分析，评估影响放射性皮炎发生率的因素。2002年9月至2009年7月间，158例乳腺癌患者接受手术后辅助三维适形放射治疗。2006年11月前，90例患者接受治疗性皮肤护理组，局部使用皮质类固醇治疗急性放射性皮炎。此后，68例患者从放疗开始接受预防性局部治疗。两组在临床和治疗因素方面没有显著差异。此外，在体内研究了局部治疗对辐射诱导的皮炎的影响的可能机制。在158名患者中，辐射诱导的湿性脱屑的发生率为23%。PTV内接受处方剂量107%的体积（PTV-V 107%; >28.6%）和治疗体积内接受处方剂量110%的体积（TV-V 110%; > 5.13%）以及未对受照射皮肤进行预防性局部治疗与急性放射性皮炎的发生率较高相关。预防性局部治疗的保护作用在TV-V 110%> 5.13%的患者中更明显。此外，使用辐射小鼠，我们证明局部类固醇乳膏显着减弱辐射诱导的炎症，导致炎性细胞因子和TGF-β 1的表达减少。TV-V_（110）% > 5.13%可能是放射性皮炎的重要预测指标。对受照皮肤进行预防性局部治疗可显著提高皮肤对辅助放疗的耐受性，尤其是TV-V> 110%的患者。
To assess the factors affecting the incidence of radiation-induced dermatitis in breast cancer patients treated with adjuvant 3 D conformal radiotherapy by the analysis of dosimetry and topical treatments. Between September 2002 and July 2009, 158 breast cancer patients were treated with adjuvant 3 D conformal radiotherapy after undergoing surgery. Before November 2006, 90 patients were subjected to therapeutic skin care group and topical corticosteroid therapy was used for acute radiation dermatitis. Thereafter, 68 patients received prophylactic topical therapy from the beginning of radiotherapy. The two groups did not differ significantly in respect of clinical and treatment factors. Furthermore, the possible mechanisms responsible for the effects of topical treatment on radiation-induced dermatitis were investigated in vivo. The incidence of radiation-induced moist desquamation was 23% across 158 patients. Higher volume receiving 107% of prescribed dose within PTV (PTV-V107%; >28.6%) and volume receiving 110% of prescribed dose within treated volume (TV-V110%; > 5.13%), and no prophylactic topical therapy for irradiated skin, were associated with higher incidence of acute radiation dermatitis. The protective effect of prophylactic topical treatment was more pronounced in patients with TV-V110% > 5.13%. Furthermore, using irradiated mice, we demonstrated that topical steroid cream significantly attenuated irradiation-induced inflammation, causing a decrease in expression of inflammatory cytokines and TGF-beta 1. TV-V110% > 5.13% may be an important predictor for radiation induced dermatitis. Prophylactic topical treatment for irradiated skin can significantly improve the tolerance of skin to adjuvant radiotherapy, especially for patients with higher TV-V110%.
登录
查看更多内容
咖啡酸苯乙酯在体外和体内辐射后降低急性肺炎。
影响因子：
3.8
作者：
Chen, MF;Keng, PC;Lin, PY;Yang, CT;Liao, SK;Chen, WC
通讯作者：
Chen, WC
影响因子：
51.1
作者：
Darby, SC;McGale, P;Peto, R
通讯作者：
Peto, R
DOI：
10.1016/j.ijrobp.2006.11.005
发表时间：
2007-04-01
影响因子：
7
作者：
Chen, Miao-Fen;Tseng, Chih-Jen;Chen, Wen-Cheng
通讯作者：
Chen, Wen-Cheng
DOI：
10.1016/j.ijrobp.2003.09.039
发表时间：
2004-02-01
影响因子：
7
作者：
Linard, C;Marquette, C;Mathé, D
通讯作者：
Mathé, D
影响因子：
10.3
作者：
Gebski, V;Lagleva, M;Langlands, AO
通讯作者：
Langlands, AO