Aging, Neurocognition, and Medication Adherence in HIV Infection
Aging, Neurocognition, and Medication Adherence in HIV Infection
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DOI：
10.1097/jgp.0b013e31819431bd
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发表时间：
2009-04-01
影响因子：
7.2
通讯作者：
Foley, Jessica
中科院分区：
文献类型：
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作者：
Ettenhofer, Mark L.;Hinkin, Charles H.;Foley, Jessica
目的：评估以下假设：对高效抗逆转录病毒治疗（HAART）的依从性差与老年人的认知功能障碍的相关性比年轻的HIV血清阳性成年人更强。设置和参与者：从洛杉矶地区的社区机构和大学附属传染病诊所招募了431名HIV感染的成人患者，他们接受了自我管理的HAART治疗。测量值：神经认知测量包括注意力、信息处理速度、学习/记忆、语言流畅性、运动功能和执行功能的测试。使用嵌入微芯片的药丸瓶盖（药物事件监测系统）和se报告测量药物依从性。潜/结构分析技术被用来评估认知和坚持的因素模型。结果：老年人（>= 50岁）的平均依从率高于年轻人（
Objective: To evaluate the hypothesis that poor adherence to highly active antiretroviral treatment (HAART) would be more strongly related to cognitive impairment among older than among younger HIV-seropositive adults. Setting and Participants: A volunteer sample of 431 HIV-infected adult patients prescribed self-administered HAART was recruited from community agencies and university-affiliated infectious disease clinics in the Los Angeles area. Measurements: Neurocognitive measures included tests of attention, information processing speed, learning/memory, verbal fluency, motor functioning, and executive functioning. Medication adherence was measured using microchip-embedded pill bottle caps (Medication Event Monitoring System) and se report. Latent/structural analysis techniques were used to evaluate factor models of cognition and adherence. Results: Mean adherence rates were higher among older (>= 50 years) than younger (