Why Is Propranolol Better Than Metoprolol in Acute Treatment of Electrical Storm?
Why Is Propranolol Better Than Metoprolol in Acute Treatment of Electrical Storm?
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为什么普萘洛尔在电风暴的急性治疗中比美托洛尔更好？
DOI：
10.1016/j.jacc.2018.02.058
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发表时间：
2018
影响因子：
24
通讯作者：
Doytchinova,Anisiia
中科院分区：
文献类型：
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作者：
Chen,Peng-Sheng;Doytchinova,Anisiia
在本期杂志中，Chatzidou et al. (1)60例植入型心律转复除颤器（ICD）和电风暴（ES）的患者采用1：1的双盲设计，前瞻性随机分配接受普萘洛尔（40 mg，每6 h口服一次）和美托洛尔（50 mg，每6 h口服一次）治疗。排除了索引介绍的次要原因，所有受试者均接受胺碘酮治疗。作者发现，普萘洛尔治疗的患者住院时间较短，48 h时的心肌负担和ICD放电显著减少。结果清楚地表明，普萘洛尔是一个更好的抗心律失常药物比美托洛尔急性治疗的ES患者谁已经收到胺碘酮。（二）、从那时起，ES，一种以室性心动过速（VT）和VF反复发作为特征的疾病，主要发生在ICD和心力衰竭患者中，仍然是显著发病率和死亡率的来源。交感神经系统对启动和
In this issue of the Journal, Chatzidou et al.(1) prospectively randomized 60 patients with implantable cardioverter-defibrillators (ICDs) and electrical storm (ES) in a 1: 1, double-blind design to therapy with propranolol (40 mg orally every 6 h) versus metoprolol (50 mg orally every 6 h). Secondary causes for the index presentation were excluded and all subjects received amiodarone. The authors found that patients treated with propranolol had a shorter length of stay with significantly reduced arrhythmic burden and ICD discharges at 48 h. The results clearly indicate that propranolol is a better antiarrhythmic drug than metoprolol for acute treatment of ES in those patients who have already received amiodarone.Immediate recurrences of ventricular fibrillation (VF) after a successful defibrillation shock were first observed by Zoll et al.(2). Since then, ES, a disease characterized by repeated episodes of ventricular tachycardia (VT) and VF, mostly in patients with ICDs and heart failure, continues to represent a source of significant morbidity and mortality. The influence of the sympathetic nervous system on initiation and