Diet-derived fruit and vegetable metabolites show sex-specific inverse relationships to osteoporosis status.
Diet-derived fruit and vegetable metabolites show sex-specific inverse relationships to osteoporosis status.
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饮食来源的水果和蔬菜代谢物表现出与骨质疏松状况的性别特异性逆关系。
DOI：
10.1016/j.bone.2020.115780
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发表时间：
2021-03
期刊：
影响因子：
4.1
通讯作者：
Parnell LD
中科院分区：
文献类型：
--
作者：
Mangano KM;Noel SE;Lai CQ;Christensen JJ;Ordovas JM;Dawson-Hughes B;Tucker KL;Parnell LD
营养对骨质疏松症（OS）代谢特征的影响尚不清楚。使用非靶向代谢组学方法确定推动水果和蔬菜（FV）摄入量与OS患病率相关的生化因素。从波士顿波多黎各骨质疏松症研究中检查了横断面饮食、人体测量和血浆代谢物数据，n=600（46- 79岁）。骨密度测定采用DXA。OS由临床标准定义。文化适应FFQ评估通常的饮食摄入量。42个FV项目的主成分分析（PCA）产生6个因子。在商业平台上评估了血浆样本的代谢组学特征。使用逻辑回归比较疾病组之间525种血浆代谢物水平的差异（OS与无OS）;并通过多变量线性回归调整协变量与FV摄入量的相关性。使用Mbrole 2.0、MetaboAnalyst和Reactome，使用P值的FDR校正，分析与OS状态或总FV摄入量显著相关的代谢物在各种生物途径中的富集。相关系数计算为斯皮尔曼rho秩相关，然后使用PCA FV因子和OS相关代谢物的性别特异性组对所得相关系数进行分层聚类。高FV摄入与OS患病率呈负相关（比值比= 0.73; 95% CI = 0.57，0.94; P = 0.01）。与FV相关的代谢物，包括咖啡因代谢，肉毒碱和脂肪酸，和甘油磷脂的几个生物过程。与OS相关的代谢物确定的重要过程是女性类固醇激素的生物合成和男性支链氨基酸代谢。来自五氯苯甲醚的因素与OS相关代谢物相关，深色绿叶蔬菜和浆果/瓜类的高摄入量对两性都有保护作用。这些数据值得调查增加深色绿叶蔬菜，浆果和甜瓜的摄入量是否会通过性别特异性代谢途径影响中老年骨质疏松症风险的骨转换和BMD，以及基因-饮食相互作用如何改变这些性别特异性代谢-骨质疏松症联系。
The impact of nutrition on the metabolic profile of osteoporosis (OS) is unknown. Identify biochemical factors driving the association of fruit and vegetable (FV) intakes with OS prevalence using an untargeted metabolomics approach. Cross-sectional dietary, anthropometric and plasma metabolite data were examined from the Boston Puerto Rican Osteoporosis Study, n=600 (46–79yr). Bone mineral density was assessed by DXA. OS was defined by clinical standards. A culturally adapted FFQ assessed usual dietary intake. Principal components analysis (PCA) of 42 FV items created 6 factors. Metabolomic profiles derived from plasma samples were assessed on a commercial platform. Differences in levels of 525 plasma metabolites between disease groups (OS vs no-OS) were compared using logistic regression; and associations with FV intakes by multivariable linear regression, adjusted for covariates. Metabolites significantly associated with OS status or with total FV intake were analyzed for enrichment in various biological pathways using Mbrole 2.0, MetaboAnalyst, and Reactome, using FDR correction of P-values. Correlation coefficients were calculated as Spearman’s rho rank correlations, followed by hierarchical clustering of the resulting correlation coefficients using PCA FV factors and sex-specific sets of OS-associated metabolites. High FV intake was inversely related to OS prevalence (Odds Ratio = 0.73; 95% CI = 0.57, 0.94; P = 0.01). Several biological processes affiliated with the FV-associating metabolites, including caffeine metabolism, carnitines and fatty acids, and glycerophospholipids. Important processes identified with OS-associated metabolites were steroid hormone biosynthesis in women and branched-chain amino acid metabolism in men. Factors derived from PCA were correlated with the OS-associated metabolites, with high intake of dark leafy greens and berries/melons appearing protective in both sexes. These data warrant investigation into whether increasing intakes of dark leafy greens, berries and melons causally affect bone turnover and BMD among middle-aged and older adults at risk for osteoporosis via sex-specific metabolic pathways, and how gene-diet interactions alter these sex-specific metabolomic-osteoporosis links.
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影响因子：
3.4
作者：
Baek JM;Ahn SJ;Cheon YH;Lee MS;Oh J;Kim JY
通讯作者：
Kim JY
影响因子：
6
作者：
Deepak, Vishwa;Kruger, Marlena C.;Coetzee, Magdalena
通讯作者：
Coetzee, Magdalena
DOI：
10.1152/ajpendo.00130.2007
发表时间：
2007-08-01
影响因子：
5.1
作者：
Borst, Stephen E.;Conover, Christine F.;Wronski, Thomas J.
通讯作者：
Wronski, Thomas J.
影响因子：
6.6
作者：
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通讯作者：
Clark, Richard V.
影响因子：
5.9
作者：
Boeyens JC;Deepak V;Chua WH;Kruger MC;Joubert AM;Coetzee M
通讯作者：
Coetzee M