The molecular architecture of the plant nuclear pore complex.
The molecular architecture of the plant nuclear pore complex.
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DOI：
10.1093/jxb/ers258
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发表时间：
2013-02
影响因子：
6.9
通讯作者：
K. Tamura;I. Hara-Nishimura
中科院分区：
文献类型：
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作者：
K. Tamura;I. Hara-Nishimura
细胞核包含细胞的遗传物质，通过基因调控指导细胞活动。核被膜的物理屏障需要对各种大分子和信号是可渗透的。大分子转运的最主要通道是核孔复合物（NPC）。NPC是细胞中最大的多蛋白复合物，由约30种不同蛋白质的多个拷贝组成，称为核孔蛋白。虽然在脊椎动物和酵母中的NPC结构的解剖已经取得了很大的进展，在植物中的核孔蛋白的分子结构和生理功能仍然知之甚少。在这篇综述中，我们总结了目前的知识，植物NPC蛋白质组和地址的结构和功能方面的植物核孔蛋白，支持基本的细胞机器。
The nucleus contains the cell's genetic material, which directs cellular activity via gene regulation. The physical barrier of the nuclear envelope needs to be permeable to a variety of macromolecules and signals. The most prominent gateways for the transport of macromolecules are the nuclear pore complexes (NPCs). The NPC is the largest multiprotein complex in the cell, and is composed of multiple copies of ~30 different proteins called nucleoporins. Although much progress has been made in dissecting the NPC structure in vertebrates and yeast, the molecular architecture and physiological function of nucleoporins in plants remain poorly understood. In this review, we summarize the current knowledge regarding the plant NPC proteome and address structural and functional aspects of plant nucleoporins, which support the fundamental cellular machinery.