Surface-reactive acrylic copolymer for fabrication of microfluidic devices.
Surface-reactive acrylic copolymer for fabrication of microfluidic devices.
复制标题
用于制造微流体装置的表面反应性丙烯酸共聚物。
DOI：
10.1021/ac0580060
复制
发表时间：
2005
影响因子：
7.4
通讯作者：
Lee,MiltonL
中科院分区：
文献类型：
--
作者：
Liu,Jikun;Sun,Xuefei;Lee,MiltonL
A surface-reactive acrylic polymer, poly(glycidyl methacrylate-co-methyl methacrylate) (PGMAMMA), was synthesized and evaluated for suitability as a substrate for fabrication of microfluidic devices for chemical analysis. This polymer has good thermal and optical properties and is mechanically robust for cutting and hot embossing. A key advantage of this polymeric material is that the surface can be easily modified to control inertness and electroosmotic flow using a variety of chemical procedures. In this work, the procedures for aminolysis, photografting of linear polyacrylamide, and atom-transfer radical polymerization on microchannel surfaces in PGMAMMA substrates were developed, and the performance of resultant microfluidic electrophoresis devices was demonstrated for the separation of amino acids, peptides, and proteins. Separation efficiencies as high as 4.6 × 104plates for a 3.5-cm-long separation channel were obtained. The results indicate that PGMAMMA is an excellent substrate for microfabricated fluidic devices, and a broad range of applications should be possible.
