One‐Pot Tandem Coupling Method for the Short‐Step Formal Synthesis of Riccardin C
One‐Pot Tandem Coupling Method for the Short‐Step Formal Synthesis of Riccardin C
复制标题
一锅串联偶联法短步正式合成 Riccardin C
DOI：
10.1002/chem.202203805
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Ueno Masaharu
中科院分区：
文献类型：
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作者：
Kobatake Miho;Miyoshi Norikazu;Ueno Masaharu
一锅反应减少了试剂用量并规避了工艺处理，例如多步反应中的后处理和纯化。在这项研究中，我们通过一锅反应，通过两个Sonogashira偶联反应和一个Suzuki偶联反应同时连接四个单元，然后进行还原和脱保护，实现了riccardin C的正式全合成。因此，这种一锅法包括五个步骤，不需要纯化中间反应混合物，节省了试剂和溶剂等资源，并加快了工作进程。
One‐pot reactions reduce reagent amounts and circumvent process treatments, such as work‐up and purifications in multi‐step reactions. In this study, we achieved the formal total synthesis of riccardin C through a one‐pot reaction by simultaneously linking four units through two Sonogashira coupling reactions and one Suzuki coupling reaction, followed by reduction and deprotection. Thus, this one‐pot method comprised five steps and did not require the purification of intermediate reaction mixtures, which saves resources, such as reagents and solvents, and expedites the work process.