Mask wearing in pre-symptomatic patients prevents SARS-CoV-2 transmission: An epidemiological analysis
Mask wearing in pre-symptomatic patients prevents SARS-CoV-2 transmission: An epidemiological analysis
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DOI：
10.1016/j.tmaid.2020.101803
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发表时间：
2020-07-01
影响因子：
12
通讯作者：
Yan, Wei-Hua
中科院分区：
文献类型：
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作者：
Hong, Lu-Xiao;Lin, Aifen;Yan, Wei-Hua
目标：COVID-19大流行已成为全球公共卫生领域的重大优先事项。为缓解病毒传播，实施了包括旅行限制和佩戴口罩在内的综合战略。然而，目前还没有社区传播的详细信息。方法：对2020年1月23日至3月1日在浙江省台州市确诊的SARS-CoV-2病例127例（中位年龄46岁，范围11 ~ 80岁），男71例，女56例。从电子病历和有效的个人问卷中回顾性检索这些病例的流行病学轨迹和临床特征。结果：发病时间为2020年1月9日至2月14日。其中本地居民64例，限行前1月10日至24日从武汉回国的63例。当地居民与41例武汉归来症状前患者有明确密切接触者197人，其中有123人与未戴口罩的武汉归来症状前患者有过接触，74人与未戴口罩的武汉归来患者有过接触。数据显示，当地居民密切接触未戴口罩的武汉归国前症状患者的新冠肺炎发病率明显高于其他人群（19.0% vs 8.1%, p < 0.001）。在57例密切接触者中，有21例来自有症状前武汉归国夫妇的连续本地COVID-19患者，表明在拥挤的空间密集聚集是SARS-CoV-2传播的高风险。结论：我们的研究结果提供了症状前患者佩戴口罩和限制拥挤空间人群聚集的宝贵细节，特别是减少SARS-CoV-2传播的重要干预措施。
Objectives: Pandemic COVID-19 has become a seriously public health priority worldwide. Comprehensive strategies including travel restrictions and mask-wearing have been implemented to mitigate the virus circulation. However, detail information on community transmission is unavailable yet.Methods: From January 23 to March 1, 2020, 127 patients (median age: 46 years; range: 11-80) with 71 male and 56 female, were confirmed to be infected with the SARS-CoV-2 in Taizhou, Zhejiang, China. Epidemiological trajectory and clinical features of these COVID-19 cases were retrospectively retrieved from electronic medical records and valid individual questionnaire.Results: The disease onset was between January 9 to February 14, 2020. Among them, 64 patients are local residents, and 63 patients were back home from Wuhan from January 10 to 24, 2020 before travel restriction. 197 local residents had definite close-contact with 41 pre-symptomatic patients back from Wuhan. 123 and 74 of them contact with mask-wearing or with no mask-wearing pre-symptomatic patients back from Wuhan, respectively. Data showed that incidence of COVID-19 was significantly higher for local residents close-contact with no mask-wearing Wuhan returned pre-symptomatic patients (19.0% vs. 8.1%, p < 0.001). Among 57 close contact individuals, 21 sequential local COVID-19 patients originated from a pre-symptomatic Wuhan returned couple, indicated dense gathering in congested spaces is a high risk for SARS-CoV-2 transmission.Conclusions: Our findings provided valuable details of pre-symptomatic patient mask-wearing and restriction of mass gathering in congested spaces particularly, are important interventions to mitigate the SARS-CoV-2 transmission.