Sperm competition, immunity, selfish genes and cancer.
Sperm competition, immunity, selfish genes and cancer.
复制标题
精子竞争、免疫、自私基因和癌症。
DOI：
10.1007/s00018-008-8238-4
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Lewis Z
中科院分区：
文献类型：
--
作者：
Lewis Z
精子竞争是普遍存在的，并在塑造男性生殖特征方面发挥了重要作用，如睾丸大小和产生的精子数量，这反映在许多生殖基因的快速进化中。此外，精子竞争与精液的快速进化有关。然而，我们对许多被认为在精子竞争中很重要的性状的分子基础的理解是初步的。此外，精子竞争和一系列与生殖没有直接关系的问题之间的联系才刚刚开始被探索。这些包括精子竞争和自私基因，免疫和疾病，如癌症之间的关联。我们简要回顾这些主题，并提出我们认为值得进一步研究的领域。
Sperm competition is widespread and has played an important role in shaping male reproductive characters such as testis size and numbers of sperm produced, and this is reflected in the rapid evolution of many reproductive genes. Additionally, sperm competition has been implicated in the rapid evolution of seminal fluids. However, our understanding of the molecular basis of many traits thought to be important in sperm competition is rudimentary. Furthermore, links between sperm competition and a range of issues not directly related to reproduction are only just beginning to be explored. These include associations between sperm competition and selfish genes, immunity and diseases such as cancer.We briefly review these topics and suggest areas we consider worthy of additional research.