A deep brain photoreceptive molecule in the toad hypothalamus
A deep brain photoreceptive molecule in the toad hypothalamus
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DOI：
10.1016/s0014-5793(98)00139-2
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发表时间：
1998-03-06
期刊：
影响因子：
3.5
通讯作者：
Fukada, Y
中科院分区：
文献类型：
--
作者：
Yoshikawa, T;Okano, T;Fukada, Y
我们从蟾蜍下丘脑cDNA文库中克隆了一个编码脑深部光感受分子的cDNA克隆。推导的氨基酸序列与脊椎动物视网膜视蛋白中的频视蛋白相似性最高（75-76%），表明蟾蜍频视蛋白在脑深部表达。抗体对蟾蜍视紫红质染色的细胞体和前视前核接触脑脊液的神经元的旋钮状结构的C-末端尾部。这一区域在繁殖行为中起着重要作用，表明蟾蜍视紫红质作为光周期性腺反应的光传感器。(C)1998年欧洲生物化学学会联合会。
We have isolated a cDNA clone encoding a deep brain photoreceptive molecule from the hypothalamic cDNA library of the toad, Bufo japonicus. The deduced amino acid sequence showed the highest similarity to that of pinopsin (75-76%) among vertebrate retinal opsins, indicating the expression of toad pinopsin in the deep brain. Antibodies raised against the C-terminal tail of toad pinopsin stained cell bodies and the knoblike structures of the cerebrospinal fluid-contacting neurons in the anterior preoptic nucleus. This region is known to play an important role in breeding behavior, suggesting that toad pinopsin acts as a photosensor for the photoperiodic gonadal response. (C) 1998 Federation of European Biochemical Societies.