P63 and EGFR as prognostic predictors in stage IIB radiation-treated cervical squamous cell carcinoma
P63 and EGFR as prognostic predictors in stage IIB radiation-treated cervical squamous cell carcinoma
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DOI：
10.1016/s0090-8258(03)00504-3
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发表时间：
2003-11-01
影响因子：
4.7
通讯作者：
Song, KJ
中科院分区：
文献类型：
--
作者：
Cho, NH;Kim, YB;Song, KJ
背景。本研究的目的是回顾性确定接受放疗和同步化疗的FIGO期HB宫颈癌患者的p63、p53相关基因、表皮生长因子受体（EGFR）和自发性细胞凋亡与放疗的关系。 材料和方法。本研究纳入了1991年至1996年间接受放疗和同步化疗的84名FIGO IIB期宫颈鳞状细胞癌（SCC）患者。将临床病理特征、治疗失败模式和生存数据与通过免疫组织化学测定的 p63 和 EGFR 的表达以及组织阵列载玻片上 TUNEL 测定的细胞凋亡进行比较。进行单变量和多变量分析以确定影响患者生存的预后因素。结果。总体而言，IIB期宫颈癌中p63和EGFR的表达指数分别为18.7%和26.6%，并且发现它们具有相关性。 EGFR 表达与盆腔外衰竭显着相关（P = 0.03），而 p63 与局部区域衰竭相关（P = 0.03）。自发性细胞凋亡指数没有显示出预后价值，但单变量（分别为 P = 0.01 和 0.04）和多变量分析（分别为 95% CI：2.0-4.4，RR：3.2 和 95% CI：4.9-8.7，RR：6.7）显示 p63 和 EGFR 的免疫反应性与较差的预后相关。结论。 p63 基因的表达与较差的生存率和局部区域衰竭相关，而 EGFR 的表达被发现是盆腔外衰竭的预后预测因子。这两种分子被发现是接受过放疗和同步化疗的FIGO IIB期宫颈鳞状细胞癌患者的有效分子危险因素。 (C) 2003 Elsevier Inc. 保留所有权利。
Background. The purpose of this study was to determine the relation between p63, p53-related gene, epidermal growth factor receptor (EGFR), and spontaneous apoptosis in relation to radiotherapy in patients with FIGO stage HB cervical carcinoma, who had undergone radiation and concurrent chemotherapy, retrospectively.Materials and methods. Eighty-four patients with FIGO stage IIB squamous cell carcinoma (SCC) of the uterine cervix, who were treated with radiotherapy and concurrent chemotherapy between 1991 and 1996, were included in the present study. The clinicopathologic features, patterns of treatment failure, and survival data were compared with the expressions of p63 and EGFR, which were determined by immunohistochemistry and with apoptosis by TUNEL on tissue-arrayed slides. Univariate and multivariate analyses were performed to determine the prognostic factors that influence patient survival.Results. Overall the indices of the expressions of p63 and EGFR in stage IIB cervical carcinoma were 18.7 and 26.6%, respectively, and these were found to be correlated. EGFR expression was significantly associated with extrapelvic failure (P = 0.03), whereas p63 was associated with locoregional failure (P = 0.03). The spontaneous apoptotic index showed no prognostic value, but the immunoreactivities of p63 and EGFR were associated with a worse prognosis by both univariate (P = 0.01 and 0.04, respectively) and multivariate analysis (95% CI:2.0-4.4, RR:3.2 and 95% CI:4.9-8.7, RR:6.7, respectively).Conclusions. The expression of p63 gene is associated with poor survival and locoregional failure, whereas EGFR expression was found to be a prognostic predictor of extrapelvic failure. Both molecules were found to be potent molecular risk factors in patients with FIGO stage IIB SCC of the uterine cervix, who had received radiotherapy and concurrent chemotherapy. (C) 2003 Elsevier Inc. All rights reserved.