Roles nrf2 plays in myeloid cells and related disorders.
Roles nrf2 plays in myeloid cells and related disorders.
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DOI：
10.1155/2013/529219
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发表时间：
2013
影响因子：
--
通讯作者：
Yamamoto M
中科院分区：
文献类型：
--
作者：
Kobayashi E;Suzuki T;Yamamoto M
Keap1-Nrf2系统保护动物免受氧化和亲电应激。Nrf2是一种转录因子，可诱导活性氧（ROS）和细胞毒性亲电试剂解毒所需基因的表达。Keap1是一种应激传感器蛋白，在非应激条件下与Nrf2结合并泛素化，导致Nrf2的快速蛋白酶体降解。在暴露于压力下，Keap1被修饰并失活，这允许Nrf2积累并激活一系列细胞保护基因的转录。抗氧化和解毒活动对许多类型的细胞都很重要，以避免DNA损伤和细胞死亡。最近越来越多的证据表明，Nrf2也是骨髓细胞的主要功能所必需的，包括吞噬、炎症调节和产生ROS进行杀菌活动。事实上，几个小鼠模型的结果表明，髓细胞中Nrf2的表达对于炎症、抗肿瘤免疫和动脉粥样硬化的适当调节是必需的。此外，炎症产生的一些分子激活Nrf2。虽然Nrf2介导的ROS解毒被认为是抗炎所必需的，但Nrf2介导的髓细胞主要功能调节的全貌尚未阐明。在这篇综述中，我们介绍了骨髓细胞的Nrf2诱导剂的特点和Nrf2对疾病的贡献。
The Keap1-Nrf2 system protects animals from oxidative and electrophilic stresses. Nrf2 is a transcription factor that induces the expression of genes essential for detoxifying reactive oxygen species (ROS) and cytotoxic electrophiles. Keap1 is a stress sensor protein that binds to and ubiquitinates Nrf2 under unstressed conditions, leading to the rapid proteasomal degradation of Nrf2. Upon exposure to stress, Keap1 is modified and inactivated, which allows Nrf2 to accumulate and activate the transcription of a battery of cytoprotective genes. Antioxidative and detoxification activities are important for many types of cells to avoid DNA damage and cell death. Accumulating lines of recent evidence suggest that Nrf2 is also required for the primary functions of myeloid cells, which include phagocytosis, inflammation regulation, and ROS generation for bactericidal activities. In fact, results from several mouse models have shown that Nrf2 expression in myeloid cells is required for the proper regulation of inflammation, antitumor immunity, and atherosclerosis. Moreover, several molecules generated upon inflammation activate Nrf2. Although ROS detoxification mediated by Nrf2 is assumed to be required for anti-inflammation, the entire picture of the Nrf2-mediated regulation of myeloid cell primary functions has yet to be elucidated. In this review, we describe the Nrf2 inducers characteristic of myeloid cells and the contributions of Nrf2 to diseases.
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影响因子：
10.5
作者：
Itoh, K;Wakabayashi, N;Yamamoto, M
通讯作者：
Yamamoto, M
DOI：
10.1073/pnas.172398899
发表时间：
2002-09-03
影响因子：
11.1
作者：
Dinkova-Kostova, AT;Holtzclaw, WD;Talalay, P
通讯作者：
Talalay, P
影响因子：
3.9
作者：
Hayes, JD;Chanas, SA;Yamamoto, M
通讯作者：
Yamamoto, M
影响因子：
7.4
作者：
Athale, Janhavi;Ulrich, Allison;MacGarvey, Nancy Chou;Bartz, Raquel R.;Welty-Wolf, Karen E.;Suliman, Hagir B.;Piantadosi, Claude A.
通讯作者：
Piantadosi, Claude A.
影响因子：
82.9
作者：
通讯作者：
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