Sexual fidelity trade-offs promote regulatory variation in the prairie vole brain
Sexual fidelity trade-offs promote regulatory variation in the prairie vole brain
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DOI：
10.1126/science.aac5791
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发表时间：
2015-12-11
期刊：
影响因子：
56.9
通讯作者：
Phelps, Steven M.
中科院分区：
文献类型：
--
作者：
Okhovat, Mariam;Berrio, Alejandro;Phelps, Steven M.
社会行为的个体差异似乎无处不在，但我们对它与大脑多样性的关系知之甚少。在一夫一妻制的草原田鼠中，与空间记忆相关的大脑区域中血管加压素受体（由avpr1a基因编码）的水平可以预测雄性田鼠在野外的空间使用和性忠诚度。我们发现，男性忠诚和不忠的好处之间的权衡反映在模式的领土入侵，后代的父系，avpr1a表达，和替代avpr1a等位基因的进化适应性。在avpr1a基因座的DNA变异包括多态性，可靠地预测表观遗传状态和神经表达的avpr1a，和DNA多样性的模式表明，avpr1a的监管变异已被选择的青睐。在草原田鼠中，社会行为的适应性后果的权衡似乎促进了神经元和分子的多样性。
Individual variation in social behavior seems ubiquitous, but we know little about how it relates to brain diversity. Among monogamous prairie voles, levels of vasopressin receptor ( encoded by the gene avpr1a) in brain regions related to spatial memory predict male space use and sexual fidelity in the field. We find that trade-offs between the benefits of male fidelity and infidelity are reflected in patterns of territorial intrusion, offspring paternity, avpr1a expression, and the evolutionary fitness of alternative avpr1a alleles. DNA variation at the avpr1a locus includes polymorphisms that reliably predict the epigenetic status and neural expression of avpr1a, and patterns of DNA diversity demonstrate that avpr1a regulatory variation has been favored by selection. In prairie voles, trade-offs in the fitness consequences of social behaviors seem to promote neuronal and molecular diversity.