Colic in breast‐milk‐fed infants: treatment by temporary substitution of Neocate infant formula
Colic in breast‐milk‐fed infants: treatment by temporary substitution of Neocate infant formula
复制标题
母乳喂养婴儿绞痛：临时替代 Neocate 婴儿配方奶粉治疗
DOI：
10.1111/j.1651-2227.2000.tb00388.x
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发表时间：
2000
期刊：
影响因子：
3.8
通讯作者：
A. Kulczycki
中科院分区：
文献类型：
--
作者：
DC Estep;A. Kulczycki
婴儿绞痛是一种常见的问题，其特点是过度哭泣和大惊小怪。我们研究了纯母乳喂养的婴儿的绞痛症状是否会通过暂时替代母乳的氨基酸婴儿配方奶粉Neocate得到改善。使用巴尔式婴儿行为日记对6名绞痛婴儿进行了为期3 - 5天的基线期研究，同时继续纯母乳喂养，随后进行为期4 - 8天的纯Neocate喂养干预期。在干预期间，所有婴儿的痛苦行为都有所改善; 6名婴儿中有5名在1 - 2天内改善。对于1天的Neocate喂养后，总记录的哭泣和大惊小怪的时间平均减少了42%，每天减少1.0至3.1小时。基线时与单独使用Neocate期间的哭闹时间存在显著差异。与Neocate干预措施同时，母亲严格避免所有牛奶和乳制品。在绞痛症状改善后，婴儿重新开始母乳喂养，6名婴儿中有4名婴儿的耐受性相当好。两名婴儿在恢复母乳喂养后迅速复发哭泣和烦躁，在随后重新开始母乳喂养之前需要额外的Neocate喂养时间。所有的婴儿表现出绞痛症状时，直接或间接攻击牛IgG（BGG），表明BGG可能在绞痛的病因作用。
Infant colic is a common problem characterized by excessive crying and fussing. We examined whether colic symptoms of exclusively breast‐milk‐fed infants would be improved by temporary substitution of Neocate, an amino acid‐based infant formula, for breast milk. Six infants with colic were studied using Barr‐type infant behavior diaries for a 3‐5 d baseline period while they continued exclusive breast‐milk‐feeding, followed by a 4‐8 d intervention period of exclusive Neocate feeding. All infants showed improvement in distressed behavior during intervention; five of the six improved within 1‐2 d. For the period after 1 d of Neocate feeding, the total recorded crying and fussing time was reduced by an average of 42%, representing a decrease of 1.0 to 3.1 h daily. A significant difference was found between cry and fuss time at baseline versus during exclusive Neocate use. Concurrent with Neocate intervention, mothers strictly avoided all milk and dairy products. After colic symptoms improved, infants were reintroduced to breast milk, which was reasonably well tolerated in four of the six infants. Two infants had rapid recurrences of crying and fussing upon return to breastfeeding and required an additional period of Neocate feedings before subsequent reintroduction to breastfeeding. All infants exhibited colic symptoms when directly or indirectly challenged with bovine IgG (BGG), suggesting that BGG may play an etiologic role in colic.
影响因子：
8
作者：
Clyne,PS;KulczyckiJr,A
通讯作者：
KulczyckiJr,A