Canopy Homolog 2 contributes to liver oncogenesis by promoting unfolded protein response-dependent destabilization of tumor protein P53.
Canopy Homolog 2 contributes to liver oncogenesis by promoting unfolded protein response-dependent destabilization of tumor protein P53.
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Canopy Homolog 2 通过促进肿瘤蛋白 P53 的未折叠蛋白反应依赖性去稳定性来促进肝脏肿瘤发生。
DOI：
10.1002/hep.32318
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Li,Zihai
中科院分区：
文献类型：
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作者：
Hong,Feng;Lin,ChingYing;Yan,Jingyue;Dong,Yizhou;Ouyang,Yuli;Kim,Doyeon;Zhang,Xiaoli;Liu,Bei;Sun,Shaoli;Gu,Wei;Li,Zihai
结论与晚期 HCC 化疗相比，免疫治疗与 OS 改善相关。早期获得免疫治疗的情况存在显着差异，这可能是由于临床试验和实验疗法的获得机会不同所致。迫切需要一种综合方法来监测和消除晚期 HCC 治疗中的种族差异。
ConclusionsImmunotherapy was associated with improved OS compared with chemotherapy in advanced HCC. There are significant disparities in early access to immunotherapy, likely due to differential access to clinical trials and experimental therapies. A comprehensive approach to monitoring and eliminating racial‐ethnic disparities in the management of advanced HCC is urgently needed.