Observation of short wavelength infrared (SWIR) Cherenkov emission.
Observation of short wavelength infrared (SWIR) Cherenkov emission.
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DOI：
10.1364/ol.43.003854
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发表时间：
2018-08-15
期刊：
影响因子：
3.6
通讯作者：
Pogue BW
中科院分区：
文献类型：
--
作者：
Cao X;Jiang S;Jia M;Gunn J;Miao T;Davis SC;Bruza P;Pogue BW
由来自临床直线加速器（LINAC）的外部束辐射诱导的切伦科夫发射已经在临床前分子成像和临床成像中示出。如理论上预测的，宽光谱切伦科夫发射应该具有短波长红外（SWIR，1000-1700 nm）分量。这份报告是第一次实验观察到这种短波切伦科夫发射，引起外部光束辐射。SWIR切伦科夫发射的测量光谱与理论预测相匹配，其通量率接近可见光和近红外红光发射（Vis-NIR，400-900 nm）的1/3。在水基体模和生物组织中的成像表明对于放射治疗剂量学应用有足够的注量率。与Vis-NIR切伦科夫发射相比，SWIR切伦科夫发射检测的空间分辨率提高了约5.3倍，这在通过SWIR波长成像的临床放射治疗期间提供了更高分辨率切伦科夫发射剂量测定和分子传感的潜力的一些改进。
Cherenkov emission induced by external beam radiation from a clinical linear accelerator (LINAC) has been shown in preclinical molecular imaging and clinical imaging. The broad spectrum Cherenkov emission should have a short wavelength infrared (SWIR, 1000–1700 nm) component, as predicted theoretically. This report is the first experimental observation of this SWIR Cherenkov emission, induced by external beam radiation. The measured spectrum of SWIR Cherenkov emission matches the theoretical prediction, with a fluence rate near 1/3 of the visible and near infrared red emissions (Vis-NIR, 400-900 nm). Imaging in water based phantoms and biological tissues indicates that there is sufficient fluence rate for radiotherapy dosimetry applications. The spatial resolution is improved approximately 5.3 times with SWIR Cherenkov emission detection versus Vis-NIR Cherenkov emission, which provides some improvement in the potential for higher resolution Cherenkov emission dosimetry and molecular sensing during clinical radiotherapy by imaging with SWIR wavelengths.