Interleaved echo-planar imaging for fast multiplanar magnetic resonance temperature imaging of ultrasound thermal ablation therapy
Interleaved echo-planar imaging for fast multiplanar magnetic resonance temperature imaging of ultrasound thermal ablation therapy
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DOI：
10.1002/jmri.20157
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发表时间：
2004-10-01
影响因子：
4.4
通讯作者：
Hazle, JD
中科院分区：
文献类型：
--
作者：
Stafford, RJ;Price, RE;Hazle, JD
目的：建立一种基于交错梯度-回波-平面成像（EPI）的多平面磁共振温度成像（MRTI）技术，并在人体模型中进行验证，开发在临床扫描仪上近实时处理和显示数据的软件工具，验证在体内监测超声热消融治疗的可行性。材料和方法：温度估计使用EPI MRTI数据的复相位差相减来间接测量温度相关的水质子共振频移。软件工具开发运行在临床1.5 t磁共振扫描仪上，处理和显示犬脑和前列腺热消融治疗过程中的相关温度和热剂量学数据。结果：EPI MRTI提供了多平面采集，增加了温度敏感性和脂质抑制。相对于单平面快速梯度回波MRTI序列，EPI MRTI在同等空间和时间分辨率下，每TR的灵敏度和切片覆盖率增加了三倍。犬脑和前列腺超声热消融治疗的体内监测证明了温度和热剂量信息的有效性。结论：多平面MRTI可以监测热损伤的进展，并在近实时（小于5秒的延迟）调整治疗参数。EPI MRTI是超声热消融过程中有效的多平面监测方法。
Purpose: To develop a multiplanar magnetic resonance temperature imaging (MRTI) technique based on interleaved gradient-echo echo-planar imaging (EPI), verify in phantom, develop software tools to process and display data on a clinical scanner in near real-time, and demonstrate feasibility to monitor ultrasound thermal ablation therapy in vivo.Materials and Methods: Temperature estimation used complex phase-difference subtraction of the EPI MRTI data to indirectly measure the temperature-dependent water proton-resonance-frequency shift. Software tools were developed to run on a clinical 1.5-T MR scanner that processed and displayed relevant temperature and thermal dosimetry data during the course of thermal ablation treatments in canine brain and prostate in vivo.Results: EPI MRTI provided multi-planar acquisitions and increased temperature sensitivity and lipid suppression. Relative to a single-plane fast gradient-echo MRTI sequence at comparable spatial and temporal resolutions in phantom, EPI MRTI demonstrated a three-fold increase in sensitivity and slice coverage per TR. In vivo monitoring of ultrasound thermal ablation therapy in canine brain and prostate demonstrated the usefulness of the temperature and thermal dose information.Conclusion: Multi-planar MRTI allowed progression of thermal damage to be monitored and treatment parameters adjusted in near real-time (less than five second delay). EPI MRTI is an effective multi-planar monitoring method during ultrasound thermal ablation procedures.