UNEXPLAINED OPPORTUNISTIC INFECTIONS AND CD4+ T-LYMPHOCYTOPENIA WITHOUT HIV-INFECTION - AN INVESTIGATION OF CASES IN THE UNITED-STATES
UNEXPLAINED OPPORTUNISTIC INFECTIONS AND CD4+ T-LYMPHOCYTOPENIA WITHOUT HIV-INFECTION - AN INVESTIGATION OF CASES IN THE UNITED-STATES
复制标题
DOI：
10.1056/nejm199302113280601
复制
发表时间：
1993-02-11
影响因子：
158.5
通讯作者：
HOLMBERG, SD
中科院分区：
文献类型：
--
作者：
SMITH, DK;NEAL, JJ;HOLMBERG, SD
背景最近报道的无人类免疫缺陷病毒（HIV）感染的CD 4 + T淋巴细胞减少症患者的临床和公共卫生重要性尚不清楚。我们进行了调查，以确定特发性CD 4 + T淋巴细胞减少症患者的人口统计学，临床和免疫学特征;该综合征是流行性的还是可传播的;以及可能的原因。我们回顾了疾病控制和预防中心（CDC）艾滋病报告系统中的230,179例病例，并对符合CDC特发性CD 4 + T淋巴细胞减少症病例定义的成人和青少年的血液标本进行了访谈、病历回顾和实验室分析（
Background. The clinical and public health importance of recent reports of patients with CD4+ T-lymphocytopenia without human immunodeficiency virus (HIV) infection is unclear. We conducted investigations to determine the demographic, clinical, and immunologic features of patients with idiopathic CD4+ T-lymphocytopenia; whether the syndrome is epidemic or transmissible; and the possible causes.Methods. We reviewed 230,179 cases in the Centers for Disease Control and Prevention (CDC) AIDS Reporting System and performed interviews, medical-record reviews, and laboratory analyses of blood specimens from adults and adolescents who met the CDC case definition of idiopathic CD4+ T-lymphocytopenia (