Plasmonic Intravascular Photoacoustic Imaging for Detection of Macrophages in Atherosclerotic Plaques
Plasmonic Intravascular Photoacoustic Imaging for Detection of Macrophages in Atherosclerotic Plaques
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DOI：
10.1021/nl801852e
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发表时间：
2009-06-01
期刊：
影响因子：
10.8
通讯作者：
Emelianov, Stanislav Y.
中科院分区：
文献类型：
--
作者：
Wang, Bo;Yantsen, Evgeniya;Emelianov, Stanislav Y.
为了检测动脉粥样硬化斑块中的巨噬细胞，引入了等离子体金纳米颗粒作为血管内光声成像的造影剂。体模和体外组织研究表明，单个球形纳米粒子在530 nm波长共振，在680 nm波长产生微弱的光声信号，而由于等离子体共振耦合效应，被巨噬细胞内化的纳米粒子产生的光声信号很强。这些结果表明，血管内光声成像可以评估巨噬细胞介导的纳米颗粒的聚集，从而识别纳米颗粒的存在和位置；与富含巨噬细胞的动脉粥样硬化斑块相关。
To detect macrophages in atherosclerotic plaques, plasmonic gold nanoparticles are introduced as a contrast agent for intravascular photoacoustic imaging. The phantom and ex vivo tissue studies show that the individual spherical nanoparticles, resonant at 530 nm wavelength, produce a weak photoacoustic signal at 680 nm wavelength while photoacoustic signal from nanoparticles internalized by macrophages is very strong due to the plasmon resonance coupling effect. These results suggest that intravascular photoacoustic imaging can assess the macrophage-mediated aggregation of nanoparticles and therefore identify the presence and the location of nanoparticles; associated with macrophage-rich atherosclerotic plaques.