Comparison of extended-spectrum-β-lactamase (ESBL) carrying Escherichia coli from sewage sludge and human urinary tract infection
Comparison of extended-spectrum-β-lactamase (ESBL) carrying Escherichia coli from sewage sludge and human urinary tract infection
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DOI：
10.1016/j.envpol.2012.09.019
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发表时间：
2013-02-01
影响因子：
8.9
通讯作者：
Reinthaler, F. F.
中科院分区：
文献类型：
--
作者：
Zarfel, G.;Galler, H.;Reinthaler, F. F.
多年来，产生广谱β -内酰胺酶（ESBL）的细菌主要存在于医疗设施中。然而，在过去十年中，产生esbl的细菌已经开始扩散到社区和环境中。在本研究中，从污水污泥中收集产生esbl的大肠杆菌，分析并与ESBL-E进行比较。人类尿路感染（uti）的大肠杆菌。在两个样本组中，主要的esbl基因家族是bla(CTX-M)，这是人类感染中最普遍的esbl基因家族。尽管如此，ESBL基因的分布和额外抗生素耐药的频率在两个样本组中有所不同。然而，表型分析并没有将两种来源的分离物划分为单独的组，这表明两种样品集中有相似的菌株。我们推测，受感染人群中的ESBL大肠杆菌种群与污水污泥之间正在发生交换，最有可能是由尿路感染引起的ESBL大肠杆菌进入污水系统。(C) 2012 Elsevier Ltd.版权所有。
For many years, extended-spectrum-beta-lactamase (ESBL) producing bacteria were a problem mainly located in medical facilities. Within the last decade however, ESBL-producing bacteria have started spreading into the community and the environment. In this study, ESBL-producing Escherichia coli from sewage sludge were collected, analysed and compared to ESBL-E. coli from human urinary tract infections (UTIs). The dominant ESBL-gene-family in both sample groups was bla(CTX-M), which is the most prevalent ESBL-gene-family in human infection. Still, the distribution of ESBL genes and the frequency of additional antibiotic resistances differed in the two sample sets. Nevertheless, phenotyping did not divide isolates of the two sources into separate groups, suggesting similar strains in both sample sets. We speculate that an exchange is taking place between the ESBL E. coli populations in infected humans and sewage sludge, most likely by the entry of ESBL E. coli from UTIs into the sewage system. (C) 2012 Elsevier Ltd. All rights reserved.