Role of Senescence and Neuroprotective Effects of Telomerase in Neurodegenerative Diseases
Role of Senescence and Neuroprotective Effects of Telomerase in Neurodegenerative Diseases
复制标题
衰老和端粒酶在神经退行性疾病中的神经保护作用的作用
DOI：
10.1089/rej.2018.2115
复制
发表时间：
2019-07-18
影响因子：
2.6
通讯作者：
Geng, Xin
中科院分区：
文献类型：
--
作者：
Ding, Xuelu;Liu, Xuewen;Geng, Xin
细胞衰老的特征在于细胞增殖的不可逆停滞，并且已经被认为是阿尔茨海默病、帕金森病和其他神经退行性疾病的关键原因之一。端粒功能障碍、氧化应激、DNA损伤、衰老相关的分泌表型和线粒体功能障碍有助于细胞衰老的发展。端粒酶逆转录酶（Telomerase reverse transcriptase，TERT）是端粒酶的催化亚单位，以端粒酶RNA为模板，以端粒依赖的方式对抗细胞衰老。此外，还证实了TERT在神经退行性疾病中发挥额外的端粒和神经保护作用。本文就细胞衰老与神经退行性疾病之间的密切关系进行综述，特别是阐述了TERT在神经退行性疾病中的神经保护作用。
Cell senescence is characterized by the irreversible arrest of cell proliferation and has been implicated as one of the critical causes of Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. Telomere dysfunction, oxidative stress, DNA damage, senescence-associated secretory phenotype, and mitochondrial dysfunction contribute to the development of cellular senescence. Telomerase reverse transcriptase (TERT), which is the catalytic subunit of telomerase, can counteract cellular senescence with telomerase RNA template in a telomere-dependent manner. In addition, TERT has also been confirmed to exert extra-telomeric and neuroprotective roles in neurodegenerative diseases. In this review, we focus on the close relationship between cellular senescence and neurodegenerative diseases, and in particular, we elucidate the neuroprotective role of TERT in neurodegenerative diseases.