Occupational exposure to crystalline silica and the risk of lung cancer in Canadian men
Occupational exposure to crystalline silica and the risk of lung cancer in Canadian men
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DOI：
10.1002/ijc.28629
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发表时间：
2014-07-01
影响因子：
6.4
通讯作者：
Harris, Shelley A.
中科院分区：
文献类型：
--
作者：
Kachuri, Linda;Villeneuve, Paul J.;Harris, Shelley A.
结晶二氧化硅是一种公认的致癌物质，但在较低水平的暴露下与肺癌的联系尚未得到很好的表征。本研究探讨职业性二氧化硅暴露与肺癌的关系，以及吸烟和二氧化硅暴露对肺癌风险的联合影响。1994年至1997年间，在加拿大八个省进行了一项以人口为基础的病例对照研究。采用自填式问卷调查，获得终生职业史和有关其他危险因素的信息。职业卫生员根据浓度、频率和可靠性为每个工作分配二氧化硅暴露量。对1681例肺癌发病病例和2053例对照的资料进行Logistic回归分析，以估计优势比(OR)及其95%可信区间(CI)。模型包括对吸烟、终身住宅二手烟以及职业暴露于柴油和汽油发动机排放的调整。与未接触者相比，接触任何浓度二氧化硅的时间增加与肺癌风险的显著趋势相关(OR>；=30年：1.67年，1.21-2.24；p(趋势)=0.002)。最高三分位数的累积二氧化硅暴露与肺癌相关(OR=1.81，1.34~2.42；P(趋势)=0.004)。与未接触二氧化硅的男性相比，接触二氧化硅30年且香烟包装=40年的男性风险最高。
Crystalline silica is a recognized carcinogen, but the association with lung cancer at lower levels of exposure has not been well characterized. This study investigated the relationship between occupational silica exposure and lung cancer and the combined effects of cigarette smoking and silica exposure on lung cancer risk. A population-based case-control study was conducted in eight Canadian provinces between 1994 and 1997. Self-reported questionnaires were used to obtain a lifetime occupational history and information on other risk factors. Occupational hygienists assigned silica exposures to each job based on concentration, frequency and reliability. Data from 1681 incident lung cancer cases and 2053 controls were analyzed using logistic regression to estimate odds ratios (OR) and their 95% confidence intervals (CI). Models included adjustments for cigarette smoking, lifetime residential second-hand smoke and occupational exposure to diesel and gasoline engine emissions. Relative to the unexposed, increasing duration of silica exposure at any concentration was associated with a significant trend in lung cancer risk (OR >= 30 years: 1.67, 1.21-2.24; p(trend) = 0.002). The highest tertile of cumulative silica exposure was associated with lung cancer (OR = 1.81, 1.34-2.42; p(trend) = 0.004) relative to the lowest. Men exposed to silica for >= 30 years with >= 40 cigarette pack-years had the highest risk relative to those unexposed with