Bilateral thalamic gray matter changes in patients with restless legs syndrome
Bilateral thalamic gray matter changes in patients with restless legs syndrome
复制标题
DOI：
10.1016/j.neuroimage.2004.10.021
复制
发表时间：
2005-02-15
期刊：
影响因子：
5.7
通讯作者：
May, A
中科院分区：
文献类型：
--
作者：
Etgen, T;Draganski, B;May, A
不宁腿综合征（RLS）是一种常见的神经系统疾病的原发性不愉快的感觉与冲动，以移动腿发生在休息。特发性RLS的病因不明，迄今尚未发现脑结构异常。我们研究了51例右利手的特发性不宁腿综合征患者的两个独立样本（里根斯堡RLS组：n = 28，慕尼黑RLS组：n = 23），并将其与51名性别和年龄匹配的健康志愿者进行比较。获得每个受试者的高分辨率T1加权磁共振成像（MRI），并使用基于体素的形态测定法（VBM）进行分析，以检测患者和对照组之间灰质的区域特异性差异。采用联合分析将两个中心的结果联合收割机合并。在特发性RLS患者中，两个研究中心均独立观察到枕部双侧灰质增加。在包括来自两个研究中心的所有患者和对照的联合分析中，双侧枕灰质显著增加（右侧：x = 16，y =-21，z = 12，Z = 4.57，左侧：x =-16，y =-24，z = 12，Z = 4.10）。这是第一次证明特发性RLS患者的大脑结构变化。丘脑结构的这些变化要么参与RLS的发病机制，要么可能反映了行为相关信息的传入输入慢性增加的结果。(C)2004年爱思唯尔公司All rights reserved.
Restless legs syndrome (RLS) is a common neurological disorder of a primary unpleasant sensation with an urge to move the legs occurring at rest. The etiology of idiopathic RLS is unknown and structural cerebral abnormalities have so far not been detected. We studied 51 right-handed patients with an idiopathic restless legs syndrome in two independent samples (Regensburg RLS-group: n = 28, Munich RLS-group: n = 23) and compared them to 51 sex- and age-matched healthy volunteers. High-resolution T1-weighted magnetic resonance imaging (MRI) of each subject was obtained and analyzed using voxel-based morphometry (VBM) to detect regionally specific differences in gray matter between patients and controls. Conjunction analysis was used to combine results from both centers. In patients with idiopathic RLS, both study centers observed independently a bilateral gray matter increase in the pulvinar. In the conjunction analysis including all patients and controls from both study centers, a significant gray matter increase in the pulvinar bilaterally (right: x = 16, y = -21, z = 12, Z = 4.57, left: x = -16, y = -24, z = 12, Z = 4.10) was present. This is the first demonstration of structural changes in the brain of patients with idiopathic RLS. These changes in thalamic structures are either involved in the pathogenesis of RLS or may reflect a consequence of chronic increase in afferent input of behaviorally relevant information. (C) 2004 Elsevier Inc. All rights reserved.