Viscosity measurements utilizing a fast-fl ow micro fl uidic paper -based device
Viscosity measurements utilizing a fast-fl ow micro fl uidic paper -based device
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DOI：
10.1016/j.snb.2020.128240
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发表时间：
2020-09-15
影响因子：
8.4
通讯作者：
Henry, Charles S.
中科院分区：
文献类型：
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作者：
Jang, Ilhoon;Berg, Kathleen E.;Henry, Charles S.
传统的微流体纸基分析装置（μ PAD）利用毛细作用通过单层纸输送流体。虽然μ PAD具有许多优点，但流速通常非常慢。快速流动纸基分析设备（ffPAD）具有不同于传统μ PAD的独特和有利的流动特性。ffPAD具有在至少一侧上具有纸的中空通道，其产生cm/s的流速。在装置内，两种类型的流动相互作用以产生快速流动现象。在这项工作中，我们利用这些流动特性，创建一个粘度测量方法的生物流体。溶液粘度对于从药物制剂到临床诊断的一系列过程都很重要。所提出的方法使用小的样品体积（100 μL），而不需要参考流体或测量未知的流体性质。此外，该设备由纸、双面胶和透明膜制成，因此它仍然具有传统纸基设备的优点，如便携性、易用性和低成本。为了确认装置性能，在不同浓度下测量聚乙二醇（PEG）溶液的粘度，并且发现与商业粘度计良好一致。最后，人工唾液溶液的粘度测量也证明了生物流体的适用性。
Traditional microfluidic paper-based analytical devices (μPADs) use capillary action to transport fluids through a single layer of paper. While μPADs have many advantages, flow rates are typically quite slow. Fast-flow paper-based analytical devices (ffPADs) have unique and advantageous flow characteristics that differ from traditional μPADs. ffPADs have a hollow channel with paper on at least one side that generates flow rates of cm/s. Within the device, two types of flow interact with each other to create the fast flow phenomenon. In this work, we take advantage of these flow characteristics to create a viscosity measurement method for biofluids. Solution viscosity is important for a range processes from pharmaceutical formulations to clinical diagnostics. The proposed method uses a small sample volume (100 μL) without the need for reference fluids or measurements for unknown fluid properties. Additionally, the device is fabricated from paper, double-sided adhesive and transparency film, so it still possesses the advantages of traditional paper-based devices such as portability, ease of use, and low-cost. To confirm the device performance, viscosities of polyethylene glycol (PEG) solutions were measured at different concentrations and were found to be in good agreement with a commercial viscometer. Finally, viscosity measurements of artificial saliva solutions were also demonstrated to verify biofluid applicability.