A photo-responsive chemical modulation of m6A RNA demethylase FTO
A photo-responsive chemical modulation of m6A RNA demethylase FTO
复制标题
m6A RNA 去甲基酶 FTO 的光响应化学调节
DOI：
10.1039/d1cc04091j
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Liang Cheng
中科院分区：
文献类型：
--
作者：
Ling Lan;Ying-Jie Sun;Li Liu;Liang Cheng
腺嘌呤N6-甲基化m6 A是一种重要的修饰，与多种生物学功能相关。两种m6 A脱甲基酶之一FTO已经成为开发新型癌症疗法的有吸引力的靶标。在这里，我们描述了一种新的设计，合成和评价的光响应和选择性抑制剂的FTO。
The adenine N6-methylation m6A is a crucial modification that is associated with several biological functions. One of the two m6A demethylases FTO has arisen as an attractive target for the development of novel cancer therapies. Here, we describe a new design, synthesis and evaluation of a photo-responsive and selective inhibitor of FTO.