High Prevalence of Macrolide Resistance in Mycoplasma pneumoniae Isolates from Adult and Adolescent Patients with Respiratory Tract Infection in China
High Prevalence of Macrolide Resistance in Mycoplasma pneumoniae Isolates from Adult and Adolescent Patients with Respiratory Tract Infection in China
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DOI：
10.1086/653535
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发表时间：
2010-07-15
影响因子：
11.8
通讯作者：
Wang, Chen
中科院分区：
文献类型：
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作者：
Cao, Bin;Zhao, Chun-Jiang;Wang, Chen
356例成人呼吸道感染患者中67株肺炎支原体耐药率为69%(46/67)。所有46株大环内酯类耐药菌株都存在23S核糖体RNA基因点突变。感染大环内酯类耐药肺炎支原体的患者需要更长的抗生素治疗时间，并且有更长的退烧时间。
The resistance rate of 67 Mycoplasma pneumoniae isolates from 356 ambulatory adult patients with respiratory tract infection was 69% (46 of 67). All 46 macrolide-resistant strains harbored point mutations in the 23S ribosomal RNA gene. Patients infected with macrolide-resistant M. pneumoniae required significantly longer durations of antibiotic therapy and had longer time to resolution of fever.