Haemodynamic characterization of the isolated (denervated) parabiotically perfused rat jejunum.
Haemodynamic characterization of the isolated (denervated) parabiotically perfused rat jejunum.
复制标题
分离（去神经）联体生物灌注大鼠空肠的血流动力学特征。
DOI：
10.1111/j.1748-1716.1988.tb08312.x
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Bulkley,GB
中科院分区：
文献类型：
--
作者：
Haglund,UH;Morris,JB;Bulkley,GB
对离体（去神经）离体（parabiotic）灌注的大鼠空肠进行了基线血流动力学、血流和耗氧量自动调节以及血流动力学和无组织损伤方面的长期（3 h）稳定性表征。在短期实验中，在宽范围的灌注压（25-85 mmHg）内，抛物线灌注制剂自动调节氧消耗，但不调节血流量。当肠段进行近全缺血1小时，再灌注1小时，粘膜损伤诱导，可以预防静脉注射超氧化物歧化酶缺血后再灌注前，或别嘌呤醇缺血前。这些发现支持在无肝缺血的去神经制备中缺血后再灌注损伤的概念。因此，该制备物可作为研究大鼠肠缺血后再灌注损伤的病理生理学的改进模型。
The isolated (denervated) parabiotically perfused rat jejunum was characterized for base‐line haemodynamics, autoregulation of blood flow and oxygen consumption and long‐term (3 h) stability with respect to both haemodynamics and the absence of tissue injury. In short‐term experiments, the parabiotically perfused preparation autoregulated oxygen consumption but not blood flow over a wide range of perfusion pressures (25–85 mmHg). When the intestinal segment was subjected to near total ischaemia for 1 h, followed by 1 h of reperfusion, mucosal injury was induced which could be prevented by i.v. administration of superoxide dismutase after ischaemia just prior to reperfusion, or allopurinol prior to ischaemia. These findings support the concept of post‐ischaemic reperfusion injury in the denervated preparation without hepatic ischaemia. This preparation could thus serve as an improved model for the study of the pathophysiology of post‐ischaemic reperfusion injury in the rat intestine.