Effects of synthetic Δ9-tetrahydrocannabinol on binocular depth inversion of natural and artificial objects in man
Effects of synthetic Δ9-tetrahydrocannabinol on binocular depth inversion of natural and artificial objects in man
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DOI：
10.1007/s002130050884
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发表时间：
1999-03-01
影响因子：
3.4
通讯作者：
Emrich, HM
中科院分区：
文献类型：
--
作者：
Leweke, FM;Schneider, U;Emrich, HM
双眼深度倒置代表了对各种行为和精神状况敏感的视觉感知错觉。它受到大麻素的影响，反映了感知的相关变化。本研究调查了不同类别的自然和人工物体的双眼深度反转的差异以及合成的Delta（9）-四氢大麻酚（Dronabinol）对这些错觉的影响。使用这个模型，口服给药的屈大麻酚对双眼深度反转的影响进行了研究在17名健康男性志愿者。来自自然和人造物体的图片被立体地呈现，志愿者的深度知觉以可操作的方式被评分。就刺激类别（自然和合成物体）而言，分析了屈大麻酚对双眼深度倒置的影响的时间过程。不同刺激组的双眼深度反转差异显着。日常熟悉程度较高的物体通常比日常熟悉程度较低的物体更容易产生幻觉。在大多数类别的对象中发现了由于屈大麻酚引起的双眼深度反转的强烈损害。不同的刺激类的分析提供了进一步的信息，双目深度反演的基本感知处理。损害的自上而下的处理视觉感官数据的屈大麻酚建议。anandamidergic系统似乎涉及视觉信息处理领域。
Binocular depth inversion represents an illusion of visual perception that is sensitive to various behavioural and psychiatric conditions. It is affected by cannabinoids, reflecting associated changes in perception. The present study investigated the differences in binocular depth inversion of different classes of natural and artificial objects and the effect of synthetic Delta(9)-tetrahydrocannabinol (Dronabinol) on these illusionary perceptions. Using this model, the effects of orally administered Dronabinol on binocular depth inversion were investigated in 17 healthy male volunteers. Pictures from natural and artificial objects were presented stereoscopically and the depth perception of the volunteers was scored in an operationalized way. The timecourse of the effects of Dronabinol on binocular depth inversion was analyzed with regard to the stimulus classes (natural and synthetic objects). Significant differences in binocular depth inversion of the different groups of stimuli were revealed. Objects with a higher degree of everyday familiarity were generally seen as more illusionary than those with a lower degree of everyday familiarity. A strong impairment of binocular depth inversion due to Dronabinol was found in most classes of objects. Analysis of different stimulus classes provides further information on the underlying perceptual processing of binocular depth inversion. An impairment of top-down processing of visual sensory data by Dronabinol is suggested. The anandamidergic system seems to be involved in areas of visual information processing.