Chronic inflammatory demyelinating polyneuropathy in dogs and cats.
Chronic inflammatory demyelinating polyneuropathy in dogs and cats.
复制标题
狗和猫的慢性炎症性脱髓鞘性多发性神经病。
DOI：
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发表时间：
1996
影响因子：
3.8
通讯作者：
P. Zimmer
中科院分区：
文献类型：
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作者：
K. Braund;J. Vallat;J. Steiss;V. Panangala;P. Zimmer
在过去的几年里，我们积累了关于一种自发性脱髓鞘周围神经病的数据，这种疾病在家畜中没有得到很好的识别。这种疾病在狗和猫身上都会发生，无论性别，似乎都与品种无关。发病体征通常是隐匿性的，病程通常是慢性的，有时复发，通常是缓慢进展的。任何年龄的成熟动物都可能受到影响。临床症状包括四肢瘫痪，有时进展为四肢瘫痪，步态蹒跚和反射减退。运动神经传导速度减慢。病理上，周围神经单个纤维的变化以多灶性结旁脱髓鞘为主。半薄切片上可见散在稀疏的有髓纤维。超微结构研究显示，有髓纤维中的巨噬细胞剥离髓鞘，裸露和重新髓鞘的轴突，以及局灶性/多灶性神经内单核细胞。间接免疫荧光显示2只犬周围神经髓鞘内免疫球蛋白G染色呈阳性。其病程、临床体征、电生理和病理与人类慢性炎症性脱髓鞘多神经病有相似之处。
Over the past several years, we have accumulated data on a spontaneous demyelinating peripheral neuropathy that is not well identified in domestic animals. This disorder occurs in dogs and cats of either sex and does not appear breed-related. Onset of signs is usually insidious and the course is typically chronic, sometimes relapsing, and often slowly progressive. Mature animals of any age may be affected. Clinical signs include tetraparesis, sometimes progressing to tetraplegia, stumbling gait, and hyporeflexia. Motor nerve conduction velocities are decreased. Pathologically, changes in teased single fibers from peripheral nerves are dominated by multifocal paranodal demyelination. Scattered, thinly myelinated fibers are seen on semithin sections. Ultrastructural studies reveal macrophages within myelinated fibers stripping the myelin sheaths, naked and remyelinating axons, and focal/multifocal endoneurial mononuclear cells. Indirect immunofluorescence revealed positive IgG staining in peripheral nerve myelin sheaths from two dogs. The course of the disease, clinical signs, electrophysiology, and pathology have similarities to chronic inflammatory demyelinating polyneuropathy in people.